Exosome Diagnostics and Therapeutics: Global Markets

Summary

Initially, exosome particles were considered “garbage” molecules secreted by cells. Today, many researchers are convinced that these tiny vesicles have unlimited potential in diagnostics and therapeutics, especially in oncology treatments.

By definition, exosomes are small membrane sacs/vesicles, approximately 30 to 100 nanometers (nm) in diameter, that are released by both healthy and cancerous cells. Substances from cell cytoplasm, such as genomic DNA, various RNA species, proteins and lipids are encapsulated into exosomes and shed into the extracellular environment.

Research shows that all fluids in the human body contain exosomes which can transfer cytoplasmic ingredients to other cells either locally or at distant sites. Once reaching the recipient cells, cytoplasmic ingredients can alter their biology.

Scientists believe that various biomolecules in exosomes can be profiled and, consequently, may serve as useful biomarkers for different diseases. Nucleic acids such as RNA or DNA can be isolated from exosomes and further analyzed by various techniques.

This report evaluates the diagnostics market affected by exosome research and further potential of exosome-based tests and assays. Indeed, an exosomes approach represents the opportunity to expand and develop the liquid biopsy market, a growing sector in cancer diagnostics.

This report also highlights developments in therapeutics and drug development sectors. There is a significant potential for using exosome depletion as a way of treating disease; cancer-generated exosomes can inhibit the immune response and stimulate angiogenesis, the development of new blood vessels. Consequently, if these exosomes are removed, tumor growth might be inhibited, and anticancer agents can work more efficiently.

In addition, there is a potential for exosomes to be used as targeted delivery vehicles of therapeutic molecules to cancer cells; for example, delivering small interfering RNA-specific molecules (siRNA) for a particular oncogene expressed in a tumor cell.

Life science tool companies develop unique research tools for exosome detection and isolation. Current products offered in this area of industry are discussed in this report.

Although many scientific questions still need to be answered, exosomes serve as a novel and unique platform in the diagnostics and therapeutic sectors. Altogether, exosomes offer a new alternative to current diagnostics and drug development technologies."

Table of Contents

Chapter 1 Introduction

Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources and Methodology
Intended Audience
Analyst's Credentials
Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background

Exosome Definition and Nomenclature
Discovery of Exosomes
Exosomes Biogenesis and Processing
Exosome Components
DNA in Exosomes
Proteins in Exosomes
RNA in Exosomes
Isolation and Detection of Exosomes
Isolation Techniques
Exosome Detection
Bioinformatics Databases for Exosome Research and Product Development
ExoCarta
Vesiclopedia
EVpedia
Exosome Function and Physiology

Chapter 4 Exosome Diagnostics Market

Exosomal Proteins as Diagnostic Biomarkers
Exosomal Nucleic Acids as Diagnostic Biomarkers
Cancer Diagnostics as Market Potential for Exosome-based Diagnostics Product Development
Prostate Cancer as Potential for Diagnostics Development in Exosomes Sector
Breast Cancer as Potential for Diagnostics Development in Exosome Sector
Bladder Cancer as Potential for Diagnostics Development in Exosome Sector
Ovarian Cancer as Potential for Diagnostics Development in Exosome Sector
Lung Cancer as Potential for Diagnostics Development in the Exosome Sector
Liquid Biopsy as Potential for Diagnostics in Exosome Sector
Exosomal Proteins and Nucleic Acids as Cancer Biomarkers in Assay Development
CNS Disorders and Neurodegeneration Diseases as Market Potential for Exosome Diagnostics Product Development
Infectious Diseases as Market Potential for Exosome Diagnostics Product Development
Cardiovascular Diseases as Market Potential for Exosome Diagnostics Product Development
Prenatal Testing as Market Potential for Exosome Diagnostics Product Development
Organ Transplantation as Market Potential for Exosome Diagnostics Product Development
Market Participants in Exosome-based Diagnostics Sector
Amarantus BioScience
Caris Life Sciences
Exosome Diagnostics
Exosome Sciences/Aethlon Medical
Exosomics Siena SPA
Nanosomix
NX Pharmagen
NX Prenatal
Orion Pharma
Sistemic
Ymir Genomics
Additional Exosome-based Diagnostics Market Participants
Evaluation of Current Diagnostics Sector in Exosome Market

Chapter 5 Exosome Therapeutic Market

Intrinsic Therapeutic Activity of Exosomes
Immunological Compatibility
Cargo Capabilities
Generation of Exosome-mediated Therapeutics
Exosome Isolation and Purification from Biofluids or Cell Culture
Engineering Exosomes as Therapeutic Delivery Vehicles
Targeting Exosomes to Specific Recipient Cells
Designing Exosomes as a Synthetic Vector
Market Potential for Exosome Therapeutics
Market Participants in Exosome-based Therapeutics Sector
Aegle Therapeutics
Aethlon Medical
Anjarium Biosciences
BioRegenerative Sciences
Capricor Therapeutics
Cell Factory
Codiak BioSciences
Creative Medical Technology Holdings (CMTH)
DreiRosen Pharma
Evox Therapeutics
ExoCoBio
ExoCyte Therapeutics
Exogenus Therapeutics
Exopharm
Exotech Bio
Exovita Biosciences
Intrexon Corp
Kimera Labs
MDimune
MolecuVax
Panacea Pharmaceuticals, Inc.
Paradigm Pharmaceuticals
ReCyte
Regeneus
ReNeuron
Therapeutics Solutions International
Unicyte AG
Additional Pharma and Biotech Companies with Potential Exosome Research Projects
Clinical Trials as Indicator for Exosome Market Development
Evaluation of Current Therapeutics Sector in Exosome Market

Chapter 6 Exosome Reagents and Research Tools Market

Market Overview
Isolation Methodologies and Reagents for Exosome
Detection Methodologies and Reagents for Exosome Research
Characterization Methods and Reagents for Exosome Research
Engineering Methods and Reagents for Exosome Research
Additional Products and Reagents for Exosome Research
Market Participants for Reagents and Tools for Exosome Research
101Bio
AMSBIO
Cell Guidance Systems
Ciloa
Evomic Science
Excytex
ExoCan
HansaBiomed (Lonza)
IZON Science
NanoSight (Malvern Instruments)
Nanoview Biosciences
System Biosciences (SBI)
Additional Market Participants for Reagents and Tools for Exosome Research
Evaluation of Current Tools and Reagents Sector in the Exosome Market

Chapter 7 Impact of Exosome Research on Specific Biopharmaceuticals Market

Exosome Research Impact on Biomarker and Diagnostics Industry
Exosome Research Impact on MicroRNA Market
Exosome Research Impact on the Liquid Biopsy Market
Exosome Research Impact on Stem Cell Technologies Market
Exosome Research Impact on Prenatal Diagnostic Market
Exosome Research Impact on Agriculture and Food Industry
Exosome Research, Microfluidics and Nanotechnology
Exosome Research Impact on Skincare Industry

Chapter 8 Patent Review/ New Developments

Chapter 9 Market Summary

Chapter 10 Company Profiles

CODIAK BIOSCIENCES
EVOX THERAPEUTICS LTD.
EXOSOME DIAGNOSTICS INC.
HANSABIOMED LIFE SCIENCES LTD. (LONZA)
NANOSOMIX INC.
SYSTEM BIOSCIENCES (SBI)

List of Tables

Summary Table : Global Market for the Exosome Industry, by Application Sector, Through 2023
Table 1 : Nomenclature of Exosome Particles
Table 2 : Publication Trend on the Subject of Exosome, 2003-2017
Table 3 : Steps in Exosome Biogenesis and Processing
Table 4 : Proteins Essential in Exosome Biogenesis and Processing
Table 5 : Proteins Found in Exosomes
Table 6 : MicroRNA in Different Bodily Fluids
Table 7 : Methods for Exosome Isolation
Table 8 : Distribution of Exosomes Isolation Procedures in the Studies Cataloged in ExoCarta
Table 9 : Statistics of Data Cataloged in ExoCarta, 2012 and 2017
Table 10 : Statistics of Data Cataloged in Vesiclepedia, 2012 and 2017
Table 11 : Statistics of Data Cataloged in EVpedia, 2014
Table 12 : Comparison of Databases for Exosome Studies
Table 13 : Examples of Exosomal Proteins for Clinical Diagnostic Applications
Table 14 : Examples of Exosomal MicroRNA for Clinical Diagnostic Applications
Table 15 : Statistics for Prostate Cancer, 2017
Table 16 : Global Market for Prostate Cancer Diagnostics and Related Cost
Table 17 : Statistics for Breast Cancer, 2017
Table 18 : Global Market for Breast Cancer Diagnostics, Through 2019
Table 19 : Statistics for Bladder Cancer, 2017
Table 20 : Global Market for Bladder Cancer Diagnostics, 2017
Table 21 : Statistics for Ovarian Cancer, 2017
Table 22 : Global Market for Ovarian Cancer Diagnostics, 2017
Table 23 : Statistics for Lung Cancer, 2017
Table 24 : Global Market for Lung Cancer Diagnostics, 2017
Table 25 : Liquid vs. Tissue Biopsy
Table 26 : Global Market for Liquid Biopsy Including Research Tools, Services and Diagnostics, Through 2022
Table 27 : Exosomal Protein Biomarkers from Body Fluids of Patients in Pre-clinical and Clinical Studies
Table 28 : Exosomal Nucleic Acid Biomarkers in Pre-clinical and Clinical Studies
Table 29 : U.S. Statistics Data for Alzheimer’s, 2017
Table 30 : Global Market for Alzheimer’s Disease Therapeutics and Diagnostics, Through 2020
Table 31 : Global Statistics Data for Hepatitis C Infection, 2015
Table 32 : Global Market Value for Hepatitis C Diagnostics, 2017
Table 33 : U.S. Statistics Data for Cardiovascular Diseases, 2017
Table 34 : Global Market for Cardiovascular Diagnostics, 2017
Table 35 : Global Market for Prenatal Diagnostics, Predictive Tests and Neonatal Monitoring, Through 2019
Table 36 : Global Market for Organ and Tissue Transplantation Products and Devices, Through 2020
Table 37 : Comparison of Exosome-based Diagnostics Approach to Other Liquid Biopsy Platforms
Table 38 : Main Market Participants in Exosome-based Diagnostics Sector
Table 39 : Global Market for Exosome Diagnostics, Through 2023
Table 40 : Examples of Physiological Effect of Exosome Delivery
Table 41 : Top Five Vaccine Providers, 2016
Table 42 : U.S. Statistics for Burn Injuries
Table 43 : U.S. Statistics for Pressure Ulcer
Table 44 : Revenues for Aethlon Medical, 2012-2016
Table 45 : Revenue, Cost and Profits for Capricor Therapeutics, 2012-2016
Table 46 : Main Market Participants in Exosome-based Therapeutics Sector
Table 47 : Examples of Clinical Trials Related to Exosome Research
Table 48 : Examples of Financing for Exosome-based Therapeutics Companies
Table 49 : Global Market for Exosome Therapeutics, Through 2023
Table 50 : Main Steps in Exosome Research Approach
Table 51 : Examples of Commercial Kits and Reagents for Exosome Isolation
Table 52 : Percentage of Use Each of Isolation Technique for Exosome Purification
Table 53 : Examples of Detection Assay
Table 54 : Examples of Antibody Providers for Exosome Research
Table 55 : Examples of RNA Extraction Commercial Kits
Table 56 : Percentage of Use of Characterization Techniques for Exosome Sample
Table 57 : Examples of Purified Exosomes Commercial Products
Table 58 : Main Market Participants in Exosome Research Tools and Reagents
Table 59 : Global Market for Exosome Research Tools and Reagents Market, Through 2023
Table 60 : Examples of Protein Markers in Exosomes and Their Related Pathology
Table 61 : Examples of MicroRNA Markers in Exosomes and Their Related Pathology
Table 62 : Liquid vs. Tissue Biopsy
Table 63 : Global Market for Prenatal Diagnostics, Predictive Tests and Neonatal Monitoring, Through 2019
Table 64 : Number of Patents on Exosome Research Filed in Specific Years, 2000-2017
Table 65 : Examples of Patents Filed on Exosome Research
Table 66 : Search Analysis for Patents Using Specific Keywords
Table 67 : Number of Patents and Patent Applications by Some Exosome Market Participants
Table 68 : Global Market for Exosome Industry, by Application Sector, Through 2023
Table 69 : Examples of Main Market Participants in Exosome Market"

List of Figures

Summary Figure : Global Market for the Exosome Industry, by Sector, 2016-2023
Figure 1 : Publication Trend on the Subject of Exosome, 2003-2017
Figure 2 : Differential Centrifugation Process
Figure 3 : Ciliated Porous Device Designed to Isolate Exosomes by Filtration
Figure 4 : Sieving Models for Exosome Filtration
Figure 5 : Global Market for Exosome Diagnostics, 2016-2023
Figure 6 : Global Market for Exosome Therapeutics, 2016-2023
Figure 7 : Global Market for Exosome Research Tools and Reagents Market, 2016-2023
Figure 8 : Number of Patents Filed in Specific Years on Exosome Research, 2000-2017
Figure 9 : Search Analysis for Patents Using Specific Keywords
Figure 10 : Global Market for Exosome Industry, by Application Sector, 2016-2023

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