Drug Discovery Services Market by Process (Target Selection, Hit-to-Lead Identification, Lead Optimization), Type (Medicinal Chemistry, Biology Services, DMPK), Drug Type (Small Molecules, Biologics), Therapeutic Areas (Oncology, Neurology) - Forecast to 2022

Table of Contents

1 INTRODUCTION 16

1.1 OBJECTIVES OF THE STUDY 16
1.2 MARKET DEFINITION 16
1.3 MARKET SCOPE 17
1.3.1 MARKETS COVERED 17
1.3.2 YEARS CONSIDERED FOR THE STUDY 18
1.4 CURRENCY 18
1.5 LIMITATIONS 18
1.6 STAKEHOLDERS 18

2 RESEARCH METHODOLOGY 19

2.1 RESEARCH DATA 19
2.2 SECONDARY DATA 20
2.2.1 KEY DATA FROM SECONDARY SOURCES 20
2.3 PRIMARY DATA 21
2.3.1 KEY DATA FROM PRIMARY SOURCES 21
2.4 MARKET SIZE ESTIMATION 23
2.4.1 BOTTOM-UP APPROACH 23
2.4.2 TOP-DOWN APPROACH 24
2.5 DATA TRIANGULATION 25
2.6 ASSUMPTIONS FOR THE STUDY 26

3 EXECUTIVE SUMMARY 27
4 PREMIUM INSIGHTS 32

4.1 DRUG DISCOVERY SERVICES MARKET OVERVIEW 32
4.2 EUROPEAN DRUG DISCOVERY SERVICES MARKET SHARE,
BY THERAPEUTIC AREA AND COUNTRY 33
4.3 DRUG DISCOVERY SERVICES MARKET, BY TYPE 34
4.4 GEOGRAPHICAL SNAPSHOT OF THE DRUG DISCOVERY SERVICES MARKET 35

5 MARKET OVERVIEW 36

5.1 INTRODUCTION 36
5.2 MARKET DYNAMICS 36
5.2.1 DRIVERS 37
5.2.1.1 Increasing R&D expenditure 37
5.2.1.2 Increasing demand for outsourcing analytical testing and clinical trial services 38
5.2.1.3 Initiatives for research on rare diseases 39
5.2.1.4 Focus on drug discovery 40
5.2.2 RESTRAINTS 41
5.2.2.1 High cost of drug discovery and development 41
5.2.2.2 Stringent regulations governing drug discovery, and animal usage 42
5.2.3 OPPORTUNITIES 42
5.2.3.1 Introduction of advanced technologies 42
5.2.3.2 Patent expiries to boost the demand for drug discovery 42
5.2.4 BURNING ISSUES 43
5.2.4.1 Need for harmonization of regulations, IP rights 43

6 DRUG DISCOVERY SERVICES MARKET, BY PROCESS 44

6.1 INTRODUCTION 45
6.2 TARGET SELECTION 46
6.3 TARGET VALIDATION 47
6.4 HIT-TO-LEAD IDENTIFICATION 48
6.5 LEAD OPTIMIZATION 49
6.6 CANDIDATE VALIDATION 50

7 DRUG DISCOVERY SERVICES MARKET, BY TYPE 51

7.1 INTRODUCTION 52
7.2 MEDICINAL CHEMISTRY 53
7.3 BIOLOGY SERVICES 54
7.4 DRUG METABOLISM AND PHARMACOKINETICS (DMPK) 55

8 DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE 56

8.1 INTRODUCTION 57
8.2 SMALL MOLECULES 58
8.3 BIOLOGICS 59

9 DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA 60

9.1 INTRODUCTION 61
9.2 ONCOLOGY 63
9.3 NEUROLOGY 64
9.4 CARDIOVASCULAR DISEASES 65
9.5 RESPIRATORY DISEASES 66
9.6 DIABETES 67
9.7 OTHER THERAPEUTIC AREAS 68
 

10 DRUG DISCOVERY SERVICES MARKET, BY REGION 69

10.1 INTRODUCTION 70
10.2 NORTH AMERICA 71
10.2.1 US 75
10.2.2 CANADA 78
10.3 EUROPE 82
10.3.1 GERMANY 87
10.3.2 UK 90
10.3.3 FRANCE 92
10.3.4 REST OF EUROPE (ROE) 95
10.4 ASIA PACIFIC (APAC) 98
10.4.1 CHINA 102
10.4.2 JAPAN 105
10.4.3 INDIA 107
10.4.4 REST OF ASIA PACIFIC (ROAPAC) 110
10.5 REST OF THE WORLD (ROW) 112

11 COMPETITIVE LANDSCAPE 115

11.1 MARKET SHARE ANALYSIS 115

12 COMPANY PROFILES 116

(Overview, Strength of Product Portfolio, Business Strategy Excellence, Products Offering, and Recent Developments)*
12.1 THERMO FISHER SCIENTIFIC 116
12.2 MERCK 120
12.3 GE HEALTHCARE 123
12.4 ALBANY MOLECULAR RESEARCH, INC. (AMRI) 126
12.5 CHARLES RIVER LABORATORIES INTERNATIONAL 130
12.6 EVOTEC 134
12.7 PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC. (PPD) 140
12.8 JUBILANT BIOSYS 142
12.9 COVANCE 145
12.10 GENSCRIPT BIOTECH CORPORATION 148
12.11 AURIGENE DISCOVERY TECHNOLOGIES 150
12.12 WUXI APPTEC 153
12.13 SYNGENE 156
*Details on Overview, Strength of Product Portfolio, Business Strategy Excellence, Products Offering, and Recent Developments might not be captured in case of unlisted companies.
 
13 APPENDIX 159

LIST OF TABLES

TABLE 1 TOTAL GLOBAL PHARMACEUTICAL R&D SPENDING, 2012 TO 2022 (USD BILLION) 37
TABLE 2 R&D SPENDING, PHRMA MEMBER-COMPANIES (USD BILLION) 37
TABLE 3 ACTIVITIES OUTSOURCED IN THE PHARMACEUTICAL INDUSTRY (2014 VS. 2015) 38
TABLE 4 RESEARCH PROJECTS FUNDED BY IRDIRC BODIES 39
TABLE 5 AVERAGE COST OF DRUGS APPROVED BY YEAR 41
TABLE 6 DRUG DISCOVERY SERVICES MARKET, BY PROCESS, 2015–2022 (USD MILLION) 45
TABLE 7 TARGET SELECTION MARKET, BY REGION, 2015–2022 (USD MILLION) 46
TABLE 8 TARGET VALIDATION MARKET, BY REGION, 2015–2022 (USD MILLION) 47
TABLE 9 HIT-TO-LEAD IDENTIFICATION PROCESS MARKET, BY REGION,
2015–2022 (USD MILLION) 48
TABLE 10 LEAD OPTIMIZATION MARKET, BY REGION, 2015–2022 (USD MILLION) 49
TABLE 11 CANDIDATE VALIDATION MARKET, BY REGION, 2015–2022 (USD MILLION) 50
TABLE 12 DRUG DISCOVERY SERVICES MARKET, BY TYPE, 2015–2022 (USD MILLION) 52
TABLE 13 MEDICINAL CHEMISTRY SERVICES MARKET, BY REGION,
2015–2022 (USD MILLION) 53
TABLE 14 BIOLOGY SERVICES MARKET, BY REGION, 2015–2022 (USD MILLION) 54
TABLE 15 DRUG METABOLISM AND PHARMACOKINETICS SERVICES MARKET, BY REGION, 2015–2022 (USD MILLION) 55
TABLE 16 DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE, 2015–2022 (USD MILLION) 57
TABLE 17 SMALL MOLECULES MARKET, BY REGION, 2015–2022 (USD MILLION) 58
TABLE 18 BIOLOGICS MARKET, BY REGION, 2015–2022 (USD MILLION) 59
TABLE 19 GLOBAL NUMBER OF CLINICAL TRIALS IN DIFFERENT THERAPEUTIC AREAS, 2016 61
TABLE 20 GLOBAL DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 62
TABLE 21 DRUG DISCOVERY SERVICES MARKET FOR ONCOLOGY, BY REGION,
2015–2022 (USD MILLION) 64
TABLE 22 DRUG DISCOVERY SERVICES MARKET FOR NEUROLOGY, BY REGION,
2015–2022 (USD MILLION) 65
TABLE 23 DRUG DISCOVERY SERVICES MARKET FOR CARDIOVASCULAR DISEASES,
BY REGION, 2015–2022 (USD MILLION) 66
TABLE 24 DRUG DISCOVERY SERVICES MARKET FOR RESPIRATORY DISEASES, BY REGION, 2015–2022 (USD MILLION) 66
TABLE 25 DRUG DISCOVERY SERVICES MARKET FOR DIABETES, BY REGION,
2015–2022 (USD MILLION) 67
TABLE 26 DRUG DISCOVERY SERVICES MARKET FOR OTHER THERAPEUTIC AREAS,
BY REGION, 2015–2022 (USD MILLION) 68
TABLE 27 DRUG DISCOVERY SERVICES MARKET, BY REGION, 2015–2022 (USD MILLION) 71
TABLE 28 NORTH AMERICA: DRUG DISCOVERY SERVICES MARKET, BY COUNTRY,
2015–2022 (USD MILLION) 73
TABLE 29 NORTH AMERICA: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 73
TABLE 30 NORTH AMERICA: DRUG DISCOVERY SERVICES MARKET, BY TYPE,
2015–2022 (USD MILLION) 74
TABLE 31 NORTH AMERICA: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 74
TABLE 32 NORTH AMERICA: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA, 2015–2022 (USD MILLION) 75
TABLE 33 US: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 76
TABLE 34 US: DRUG DISCOVERY SERVICES MARKET, BY TYPE, 2015–2022 (USD MILLION) 77
TABLE 35 US: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 77
TABLE 36 US: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 78
TABLE 37 CANADA: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 80
TABLE 38 CANADA: DRUG DISCOVERY SERVICES MARKET, BY TYPE,
2015–2022 (USD MILLION) 80
TABLE 39 CANADA: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 81
TABLE 40 CANADA: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 81
TABLE 41 EUROPE: PHARMACEUTICAL R&D EXPENDITURE, BY COUNTRY, 2012 & 2014 83
TABLE 42 EUROPE: DRUG DISCOVERY SERVICES MARKET, BY COUNTRY/REGION,
2015 –2022 (USD MILLION) 85
TABLE 43 EUROPE: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 85
TABLE 44 EUROPE: DRUG DISCOVERY SERVICES MARKET, BY TYPE,
2015–2022 (USD MILLION) 86
TABLE 45 EUROPE: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 86
TABLE 46 EUROPE: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 87
TABLE 47 PHARMACEUTICAL R&D INVESTMENTS IN GERMANY (2010–2014) 88
TABLE 48 GERMANY: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 88
TABLE 49 GERMANY: DRUG DISCOVERY SERVICES MARKET, BY TYPE,
2015–2022 (USD MILLION) 88
TABLE 50 GERMANY: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 89
TABLE 51 GERMANY: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 89
TABLE 52 UK: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 90
TABLE 53 UK: DRUG DISCOVERY SERVICES MARKET, BY TYPE, 2015–2022 (USD MILLION) 91
TABLE 54 UK: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 91
TABLE 55 UK: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 92
TABLE 56 FRANCE: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 93
TABLE 57 FRANCE: DRUG DISCOVERY SERVICES MARKET, BY TYPE,
2015–2022 (USD MILLION) 93
TABLE 58 FRANCE: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 94
TABLE 59 FRANCE: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 94
TABLE 60 PHARMACEUTICAL R&D INVESTMENTS IN ITALY, 2009–2014 95
TABLE 61 PHARMACEUTICAL R&D EXPENDITURE IN BELGIUM, 2010–2014 96
TABLE 62 PHARMACEUTICAL PRODUCTION AND R&D EXPENDITURE IN DENMARK,
2012–2014 96
TABLE 63 ROE: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 96
TABLE 64 ROE: DRUG DISCOVERY SERVICES MARKET, BY TYPE, 2015–2022 (USD MILLION) 97
TABLE 65 ROE: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 97
TABLE 66 ROE: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 98
TABLE 67 TOTAL NUMBER OF CLINICAL TRIALS IN APAC, BY THERAPEUTIC AREA, 2016 98
TABLE 68 APAC: DRUG DISCOVERY SERVICES MARKET, BY COUNTRY/REGION,
2015–2022 (USD MILLION) 100
TABLE 69 APAC: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 100
TABLE 70 APAC: DRUG DISCOVERY SERVICES MARKET, BY TYPE, 2015–2022 (USD MILLION) 101
TABLE 71 APAC: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 101
TABLE 72 APAC: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 102
TABLE 73 CHINA: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 103
TABLE 74 CHINA: DRUG DISCOVERY SERVICES MARKET, BY TYPE,
2015–2022 (USD MILLION) 103
TABLE 75 CHINA: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 104
TABLE 76 CHINA: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 104
TABLE 77 JAPAN: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 105
TABLE 78 JAPAN: DRUG DISCOVERY SERVICES MARKET, BY TYPE,
2015–2022 (USD MILLION) 106
TABLE 79 JAPAN: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 106
TABLE 80 JAPAN: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 107
TABLE 81 INDIA: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 108
TABLE 82 INDIA: DRUG DISCOVERY SERVICES MARKET, BY TYPE, 2015–2022 (USD MILLION) 108
TABLE 83 INDIA: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 109
TABLE 84 INDIA: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 109
TABLE 85 ROAPAC: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 110
TABLE 86 ROAPAC: DRUG DISCOVERY SERVICES MARKET, BY TYPE,
2015–2022 (USD MILLION) 110
TABLE 87 ROAPAC: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 111
TABLE 88 ROAPAC: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 111
TABLE 89 ROW: DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2015–2022 (USD MILLION) 112
TABLE 90 ROW: DRUG DISCOVERY SERVICES MARKET, BY TYPE, 2015–2022 (USD MILLION) 113
TABLE 91 ROW: DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2015–2022 (USD MILLION) 113
TABLE 92 ROW: DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2015–2022 (USD MILLION) 114
 

LIST OF FIGURES

FIGURE 1 GLOBAL DRUG DISCOVERY SERVICES MARKET 17
FIGURE 2 RESEARCH DESIGN 19
FIGURE 3 BREAKDOWN OF PRIMARY INTERVIEWS: BY COMPANY TYPE,
DESIGNATION, AND REGION 22
FIGURE 4 DATA TRIANGULATION METHODOLOGY 25
FIGURE 5 DRUG DISCOVERY SERVICES MARKET, BY PROCESS,
2017 VS. 2022 (USD BILLION) 27
FIGURE 6 DRUG DISCOVERY SERVICES MARKET, BY TYPE, 2017 VS. 2022 (USD BILLION) 28
FIGURE 7 DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPE,
2017 VS. 2022 (USD BILLION) 29
FIGURE 8 DRUG DISCOVERY SERVICES MARKET, BY THERAPEUTIC AREA,
2017 VS. 2022 (USD BILLION) 30
FIGURE 9 DRUG DISCOVERY SERVICES MARKET, BY REGION, 2017 VS. 2022 (USD BILLION) 31
FIGURE 10 INCREASING DEMAND FOR OUTSOURCING OF ANALYTICAL TESTING AND CLINICAL TRIAL SERVICES TO DRIVE MARKET GROWTH 32
FIGURE 11 ONCOLOGY SEGMENT TO COMMAND THE LARGEST MARKET SHARE OF EUROPEAN DRUG DISCOVERY SERVICES MARKET IN 2017 33
FIGURE 12 MEDICINAL CHEMISTRY TO REGISTER THE HIGHEST CAGR DURING THE FORECAST PERIOD (2017-2022) 34
FIGURE 13 ASIA PACIFIC TO REGISTER THE HIGHEST CAGR BETWEEN 2017 & 2022 35
FIGURE 14 DRUG DISCOVERY SERVICES MARKET: DRIVERS, RESTRAINTS, AND OPPORTUNITIES 36
FIGURE 15 NUMBER OF REGISTERED STUDIES (2000-2017) 40
FIGURE 16 HIT-TO-LEAD IDENTIFICATION TO HOLD LARGEST MARKET SHARE IN 2017 45
FIGURE 17 MEDICINAL CHEMISTRY SEGMENT TO ACCOUNT FOR THE LARGEST SHARE OF THE DRUG DISCOVERY SERVICES MARKET 52
FIGURE 18 SMALL MOLECULES—THE LARGEST SEGMENT IN THE DRUG DISCOVERY SERVICES MARKET, BY DRUG TYPES 57
FIGURE 19 ONCOLOGY SEGMENT TO HOLD THE LARGEST SHARE IN DRUG DISCOVERY SERVICES MARKET IN 2017 61
FIGURE 20 TOTAL NUMBER OF CLINICAL TRIALS FOR ONCOLOGY (2016) 63
FIGURE 21 GEOGRAPHIC SNAPSHOT (2016): APAC MARKETS ARE EMERGING AS NEW GROWTH HOTSPOTS 70
FIGURE 22 NORTH AMERICA: DRUG DISCOVERY SERVICES MARKET SNAPSHOT 72
FIGURE 23 PHARMACEUTICAL R&D EXPENDITURE IN THE US (1990-2014) 76
FIGURE 24 TOTAL CANADIAN PHARMACEUTICAL TRADE (2004–2016) (USD BILLION) 79
FIGURE 25 YEARLY EMPLOYMENT IN MANUFACTURING PORTION OF PHARMACEUTICAL SECTOR (2005–2016) 79
FIGURE 26 PHARMACEUTICAL R&D EXPENDITURE IN EUROPE (2010–2014) 82
FIGURE 27 EUROPE: DRUG DISCOVERY SERVICES MARKET SNAPSHOT 84
FIGURE 28 APAC: DRUG DISCOVERY SERVICES MARKET SNAPSHOT 99
FIGURE 29 DRUG DISCOVERY SERVICES MARKET: MARKET SHARE (2016) 115
FIGURE 30 THERMO FISHER SCIENTIFIC: COMPANY SNAPSHOT (2016) 116
FIGURE 31 MERCK: COMPANY SNAPSHOT (2016) 120
FIGURE 32 GE HEALTHCARE: COMPANY SNAPSHOT (2016) 123
FIGURE 33 ALBANY MOLECULAR RESEARCH, INC.: COMPANY SNAPSHOT (2016) 126
FIGURE 34 CHARLES RIVER LABORATORIES INTERNATIONAL: COMPANY SNAPSHOT (2016) 130
FIGURE 35 EVOTEC: COMPANY SNAPSHOT (2016) 134
FIGURE 36 JUBILANT BIOSYS: COMPANY SNAPSHOT (2016) 142
FIGURE 37 LABCORP: COMPANY SNAPSHOT (2016) 145
FIGURE 38 GENSCRIPT BIOTECH CORPORATION: COMPANY SNAPSHOT (2016) 148
FIGURE 39 SYNGENE: COMPANY SNAPSHOT (2016) 156

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