Liquid Biopsy Research Tools, Services and Diagnostics: Global Markets

Table of Contents

Chapter 1 Introduction

Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Overview

Introduction
Scope of Report
Liquid Biopsy vs. Traditional Biopsy
Markets
Forces Driving Growth
Key Trends
Industry

Chapter 4 Technology Background

Liquid Biopsy Biomarkers
Cancer Genomics
Noninvasive Prenatal Testing (NIPT)
Circulating Tumor Cell Technologies (CTCs)
CTC Workflow

• Cell Isolation Technologies
• CTC Sample Preparation Technologies
• CTC Downstream Analysis Technologies

Comparison of Liquid Biopsy with Conventional Biopsy

• Cancer Testing
• Prenatal Testing

Chapter 5 Liquid Biopsy Initiatives

Introduction
Liquid Biopsy-Related Research and Development

• Initiatives and Programs
• Population Sequencing Projects

Chapter 6 Liquid Biopsy Applications

Introduction
Cancer Applications

• Precision Medicine
• Liquid Biopsy Biomarkers
• Cancer Market Segments

Reproductive Health Applications
Transplant Diagnostic Applications

Chapter 7 Liquid Biopsy Industry

Introduction
Sequencing Instruments Industry

• Third-Generation Sequencing Industry
• Sequencing Informatics Industry

PCR Industry

• Droplet Digital PCR Industry

CTC Capture and Detection Industry
Liquid Biopsy Assay Industry
Liquid Biopsy Cancer Screening/Early Detection Industry
Noninvasive Prenatal Testing (NIPT) Industry

Chapter 8 Industry Acquisitions and Strategic Alliances

Acquisitions
Strategic Alliances

• Key Trends
• Summary of Alliances

Chapter 9 Markets for Liquid Biopsy

Forces Driving Growth in the Markets for Liquid Biopsy

• Precision Medicine
• Rise of Tissue-Agnostic Drugs
• Genomics Initiatives
• Clinical Need for Better Diagnostics
• Role of Key Stakeholders
• Emerging ""Mega"" Applications
• COVID-19 Environment
• Rise in the Importance of China

Impact of COVID-19 on the Global Market for Liquid Biopsy
Global Market for Liquid Biopsy by Clinical Category
Global Market for Liquid Biopsy by Purpose of Analysis
Global Market for Liquid Biopsy by Biomarker Type
Global Market for Liquid Biopsy by Analysis Platform
Global Market for Noninvasive Prenatal Testing
Global Market for Liquid Biopsy in Cancer Applications

• Global Market for Liquid Biopsy for Cancer Diagnostics by Cancer Site
• Global Market for Liquid Biopsy in Cancer Applications by Purpose of Analysis
• Global Market for Liquid Biopsy in Cancer Applications by Biomarker Class
• Global Market for Liquid Biopsy in Cancer Applications by Analysis Method

Global Market for Liquid Biopsy for Transplant Diagnostics
Global Market for Liquid Biopsy by Geographic Region

Chapter 10 Patent Review/New Developments

Patents on Circulating Tumor Cell (CTC) Technologies
Patents on Exosome Technologies
Patents on Cell-Free DNA Technologies
Biomarker-Related Patents
Patent Considerations for the Use of Artificial Intelligence in Cancer Diagnostics
Lawsuits on Liquid Biopsy Patents

Chapter 11 Company Profiles

4D LIFETEC AG
ACCURAGEN INC.
ACCUROME HEALTH INC.
ADAPTIVE BIOTECHNOLOGIES INC.
ADVANCED CELL DIAGNOSTICS INC.
AGILENT TECHNOLOGIES INC.
AKADEUM LIFE SCIENCES
ALCEDIAG
AMOY DIAGNOSTICS CO., LTD.
ANGLE PLC
APOCELL INC.
APOSTLE INC.
ARCEDI BIOTECH APS
ARCHER DX
ARUP LABORATORIES
ASURAGEN INC.
AVIVA BIOMED INC.
AVIVA BIOSCIENCES
BARD1 LIFE SCIENCES LTD.
BASE GENOMICS
BAYLOR GENETICS
BECTON, DICKINSON AND CO.
BERRY GENOMICS CO., LTD.
BGI SHENZHEN
BIOCARTIS NV
BIOCEPT INC.
BIODESIX INC.
BIOFLUIDICA INC.
BIOGAZELLE
BIOLIDICS LTD.
BIOLOGICAL DYNAMICS INC.
BIOPROGNOS SL
BIO-RAD LABORATORIES INC.
BIO-TECHNE CORP.
BITBIOME INC.
BLUESTAR GENOMICS INC.
BURNING ROCK BIOTECH LTD.
C2I GENOMICS
CADEX GENOMICS CORP.
CAMBRIDGE EPIGENETIX
CANCER GENETICS INC.
CANEXIA HEALTH
CAPIO BIOSCIENCES
CAPTIS DIAGNOSTICS INC.
CAREDX INC.
CARIS LIFE SCIENCE
CEGAT GMBH
CELLMAX LIFE
CELL MICROSYSTEMS INC.
CELSEE DIAGNOSTICS
CELTIC B.V.
CHRONIX BIOMEDICAL
CIRCULOGENE THERANOSTICS
CLARET BIOSCIENCE
CLINICAL GENOMICS TECHNOLOGIES
CODIAK BIOSCIENCES
CRADLE GENOMICS
CYCLOMICS
CYGNUS BIOSCIENCES CO., LTD.
CYTOTRACK APS
DANAHER CORP.
DATAR CANCER GENETICS LTD.
DELFI DIAGNOSTICS
DIACARTA INC.
DIAGNOLOGIX LLC
DIAGNOMICS
DIAMIR BIO
DNALYTICS
DNANEXUS INC.
DOVETAIL GENOMICS LLC
EARLYDX INC.
EDP BIOTECH CORP.
EPIC SCIENCES INC.
EPIGENOMICS AG
EUROFINS SCIENTIFIC
EXACT SCIENCES CORP.
EXOSOME SCIENCES INC.
EXOPERT
EXOSOMICS SPA
EZLIFE BIO INC.
FABRIC GENOMICS
FLUXION BIOSCIENCES INC.
FREENOME INC.
GENAPSYS INC.
GENECAST INC.
GENEDX INC.
GENETRON HEALTH TECHNOLOGIES
GENESEQ BIOSCIENCES PTY LTD.
GENEXOSOME TECHNOLOGIES INC.
GENOMICTREE
GENOMONCOLOGY
GENOSABER
GENOSITY
GRAIL INC.
GUARDANT HEALTH INC.
HTG MOLECULAR DIAGNOSTICS INC.
IDL BIOTECH
ID SOLUTIONS
ILLUMINA INC.
IMMUNOVIA AB
INCELLDX INC.
INEX INNOVATE PTE. LTD.
INIVATA LTD.
INTERPACE BIOSCIENCES INC.
INVITAE INC.
INVIVOSCRIBE INC.
JABREHOO MEDTECH CO., LTD.
JBS SCIENCE INC.
KONINKLIJKE PHILIPS N.V.
LABORATORY CORP. OF AMERICA INC.
LABRINTH BIOTECH INC.
LARIAT BIOSCIENCES INC.
LEXENT BIO INC.
LIQUID BIOPSY LABS
LUCENCE DIAGNOSTICS PTE. LTD.
LUNGLIFE AI INC.
MDNA LIFE SCIENCES INC.
MDXHEALTH INC.
MEDGENOME INC.
MENARINI SILICON BIOSYSTEMS SPA
MERCK KGAA
MICAREO RARE CELL DIAGNOSTICS
MIR SCIENTIFIC
MIRXES
MURSLA LTD
MUTANTDX
MYRIAD GENETICS INC.
NAMOCELL INC.
NANOSTRING TECHNOLOGIES INC.
NANOVIEW BIOSCIENCES INC.
NATERA INC.
NAVERIS INC.
NEOGENOMICS LABORATORIES
NEO NEW ONCOLOGY GMBH
NEW ENGLAND BIOLABS
NEW HORIZON HEALTH LTD.
NIPD GENETICS
NOVIGENIX SA
NOVOGENE CO., LTD.
NRICHDX INC.
NUCLEIX
NUPROBE INC.
NX PRENATAL INC.
ONCIMMUNE HOLDINGS PLC
ONCOCYTE CORP.
ONCODNA S.A.
ONCOLAB DIAGNOSTICS GMBH
OPKO HEALTH
OTRACES INC.
OXFORD NANOPORE TECHNOLOGIES LTD.
PACIFIC BIOSCIENCES OF CALIFORNIA INC.
PANGAEA ONCOLOGY
PERSONAL GENOME DIAGNOSTICS INC.
PERSUASIVE
PFDENA INC.
PHASE SCIENTIFIC
PIERIANDX
PREDICINE INC.
PROVISTA DIAGNOSTICS INC.
QCDX LLC
QIAGEN NV
QUANTAPORE INC.
QUANTGENE INC.
QUANTUM BIOSYSTEMS INC.
QUANTUMDX
QUEST DIAGNOSTICS INC.
RARECELLS SAS
RAVGEN
REAL TIME GENOMICS INC.
RESOLUTION BIOSCIENCE INC.
ROCHE HOLDING AG
SAGA DIAGNOSTICS AB
SANOMICS LTD.
SANO GENETICS
SCREENCELL
SEEKIN
SEER INC.
SERACARE LIFE SCIENCES INC.
SEQUENCING.COM
SEVEN BRIDGES GENOMICS INC.
SINGLE TECHNOLOGIES
SINGLERA GENOMICS INC.
SMARTCACTCH
SOMALOGIC INC.
STAGE ZERO LIFE SCIENCES
STILLA TECHNOLOGIES
STRAND LIFE SCIENCES PVT., LTD.
STRATA ONCOLOGY
STRATOS GENOMICS INC.
SYAPSE
SYSMEX INOSTICS GMBH
TAILAI BIOSCIENCES CO., LTD.
TAKARA BIO INC.
TELEXOS GMBH
THERMO FISHER SCIENTIFIC INC.
TWINSTRAND BIOSCIENCES
TYMORA ANALYTICAL OPERATIONS LLC
UBIQUITY GENOMICS INC.
UNIVERSAL DIAGNOSTICS SL
VELA DIAGNOSTICS
VERACYTE
VOLITIONRX
VORTEX BIOSCIENCES
XING TECHNOLOGIES LLC
YIKON GENOMICS CO., LTD.
YOURGENE HEALTH PLC

List of Tables

Summary Table : Global Market for Liquid Biopsy, by Disease Class, Through 2025
Table 1 : Liquid Biopsy Sample Types and Characteristics
Table 2 : Scope of Liquid Biopsy Report
Table 3 : Global Market for Liquid Biopsy, by Analysis Type, Through 2025
Table 4 : Forces Driving Growth in the Market for Liquid Biopsy
Table 5 : Key Trends in the Market for Liquid Biopsy
Table 6 : Liquid Biopsy Industry Subsectors
Table 7 : Liquid Biopsy Biomarker Classes
Table 8 : Single-Cell Analysis to Identify Cancer Driver Mutations
Table 9 : Genomics-Based Oncology Workflow
Table 10 : Unique Challenges of CTC Capture and Analysis
Table 11 : CTC Workflow
Table 12 : Cell Differentiators
Table 13 : Cell Isolation Technologies and Performance
Table 14 : CTC Sample Preparation Technologies
Table 15 : Single-Cell Analysis Technologies
Table 16 : Estimated Annual Solid Biopsy Procedures Performed in the U.S. for Selected Cancers, by Cancer Indication
Table 17 : Main Risks of Needle-Based Tissue Biopsies
Table 18 : Factors in Tissue Biopsy
Table 19 : Prenatal Invasive Testing Technologies
Table 20 : Invasive vs. Noninvasive Prenatal Technologies
Table 21 : Liquid Biopsy-Related Research and Development Initiatives and Programs
Table 22 : Single-Cell Core Research Facilities
Table 23 : Population Sequencing Projects
Table 24 : Source of Foreign Biomarkers for Liquid Biopsy Applications
Table 25 : Precision Medicine Driven by Common Cancer Genetic Mutations
Table 26 : Liquid Biopsy Biomarker Types
Table 27 : Market Segments of Liquid Biopsy in Cancer Applications
Table 28 : NIPT Screening Applications
Table 29 : Ethical Issues Associated with NIPT
Table 30 : Transplant Diagnostic Applications
Table 31 : Key Segments and Trends within the Liquid Biopsy Industry
Table 32 : Advanced Sequencing Industry Company Positioning
Table 33 : Long-Read Sequencing Industry
Table 34 : Sequencing Informatics Industry
Table 35 : PCR Companies
Table 36 : Advantages of Droplet Digital PCR
Table 37 : Digital PCR Liquid Biopsy Industry
Table 38 : Main Companies of CTC Separations Industry
Table 39 : Liquid Biopsy Assay Industry: Company Focus
Table 40 : Examples of NGS-Based Liquid Biopsy Market Differentiation
Table 41 : Multi-Cancer Screening Test Desired Features
Table 42 : Shed Rates of Various Cancers
Table 43 : Cancer Screening Liquid Biopsy Industry
Table 44 : Thrive Earlier Detection (Exact Sciences) Cancer Targets
Table 45 : Colorectal Cancer Early Detection/Screening Liquid Biopsy Industry
Table 46 : Key Clinical Trials for Single- and Multi-Cancer Liquid Biopsy Assays
Table 47 : Key Companies in the NIPT Industry
Table 48 : Acquisitions in the Liquid Biopsy Industry, January 2019-January 2021
Table 49 : Strategic Alliances in the Liquid Biopsy Industry, January 2019-January 2021
Table 50 : Key Forces Driving Growth of Liquid Biopsy and Implications
Table 51 : Global Market for Liquid Biopsy, by Clinical Category, Through 2025
Table 52 : Global Market for Liquid Biopsy, by Purpose of Analysis, Through 2025
Table 53 : Global Market for Liquid Biopsy, by Biomarker Type, Through 2025
Table 54 : FDA-Approved or CE-Marked Tests with Epigenetic Component
Table 55 : Global Market for Liquid Biopsy, by Analysis Platform, Through 2025
Table 56 : Global Market for NIPT, by Purpose of Analysis, Through 2025
Table 57 : Global Market for NIPT, by Risk Type, Through 2025
Table 58 : Global Market for NIPT Diagnostics, by Biomarker Class, Through 2025
Table 59 : Global Market for NIPT, by Analysis Method, Through 2025
Table 60 : Limitations of Solid Biopsy in Cancer Applications
Table 61 : Low-Frequency Mutation Detection
Table 62 : Global Market for Liquid Biopsy for Cancer Diagnostics, by Cancer Site, Through 2025
Table 63 : Five-Year Survival Rate for Ovarian Cancer
Table 64 : National Institutes of Health Liquid Biopsy Early Detection Initiative
Table 65 : Lung Cancer Liquid Biopsy Clinical Trials
Table 66 : Global Liquid Biopsy Cancer Market, by Purpose of Analysis, Through 2025
Table 67 : MRI and Liquid Biopsy Methods
Table 68 : Early Detection Tissue of Origin Approaches
Table 69 : Global Market for Liquid Biopsy in Cancer Applications, by Biomarker Class, Through 2025
Table 70 : Global Market for Liquid Biopsy in Cancer Applications, by Analysis Method, Through 2025
Table 71 : Global Market for Liquid Biopsy in Transplant Applications, by Organ Type, Through 2025
Table 72 : Transplant Procedures Performed in the U.S., by Organ, 2018-2020
Table 73 : Global Market for Liquid Biopsy in Transplant Applications, by Purpose of Analysis, Through 2025
Table 74 : Global Market for Liquid Biopsy in Transplant Applications, by Biomarker Class, Through 2025
Table 75 : Global Market for Liquid Biopsy in Transplant Applications, by Analysis Method, Through 2025
Table 76 : Global Market for Liquid Biopsy, by Region, Through 2025
Table 77 : Global Market for Liquid Biopsy in Cancer Applications, by Region, Through 2025
Table 78 : Global Market for Liquid Biopsy for NIPT, by Region, Through 2025
Table 79 : Global Market for Liquid Biopsy in Transplant Applications, by Region, Through 2025
Table 80 : Patent Activity on Circulating Tumor Cell Technologies, by Country/Region, January 2010-June 2020
Table 81 : Patent Activity on Exosome Technologies, by Country/Region, January 2010-December 2020
Table 82 : Patent Activity on Cell-Free DNA Technologies, by Country/Region, January 2010-December 2020
Table 83 : Patent Activity on Cancer Biomarkers, by Country/Region, January 2010-December 2020
Table 84 : Status of Liquid Biopsy Patent Disputes

List of Figures

Summary Figure : Global Market for Liquid Biopsy, by Disease Class, 2019-2025
Figure 1 : How Cancer Genomics Drives Liquid Biopsy

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