Next Generation Cancer Diagnostics: Technologies and Global Markets

Table of Contents

Chapter 1 Introduction

Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Overview

Large-Scale Initiatives and Consortia
Market Size
Liquid Biopsy as a Market Driving Force
Key Trends
Industry

Chapter 4 Technologies

Diagnostics Overview
Arrays and Microfluidics (LOAC) Technologies

• DNA Microarrays
• Protein Microarrays
• Microfluidics

Multiplex Conventional Technologies
Next Generation Sequencing Technology
Polymerase Chain Reaction (PCR) Technology

Chapter 5 Liquid Biopsy Technologies

Liquid Biopsy Biomarkers
Cancer Genomics
Circulating Tumor Cell Technologies
CTC Workflow
Cell Isolation Technologies
CTC Sample Preparation Technologies
CTC Downstream Analysis Technologies
Comparison of Liquid Biopsy with Conventional Biopsy
Cancer Testing
Avatar-Driven Diagnostic Approaches

Chapter 6 Next Generation Cancer Diagnostics: Key Initiatives and Programs

Blood Profiling Atlas
Cancer-ID
Cancer Moon Shots
China Precision Medicine Initiative
ClinGen
CTC Trap Consortium
Early Cancer Detection Consortium
EpiFemCare
France Genomic Medicine Plan
Friends of Cancer Research Project
Human Cell Atlas
Immunomonitor Consortium
Integration of Imaging and Fluid-Based Tumor Monitoring
Liquid Biopsies and Imaging for Improved Cancer Care
Million Veteran Program
MedSeq
Next-Generation Single-Cell Analysis Program
Population Sequencing Projects
Precancer Atlas
Precision Medicine Initiative
Prompt
QuIP Project
Single-Cell Proteomics and Lipidomics Project
TopMed
Treehouse Childhood Cancer Initiative
Very Rare Cancer Consortium
Worldwide Innovative Networking (WIN) Consortium

• Single-Cell Research
• Cambridge Single-Cell Analysis Core Facility
• Harvard Medical School Single-Cell Core
• Mayo Medical Genome Facility
• National Center for Single-Cell Biology

Single-Cell Analysis Core

• UC San Francisco Single-Cell Analysis Center

Population Sequencing Programs

Chapter 7 Next Generation Cancer Diagnostic Applications by Cancer Site

Introduction
Bladder Cancer
Brain Cancer
Breast Cancer

• Breast Cancer Screening
• Prognosis and Pharmacogenetics Tests
• Breast Cancer MDx Platforms
• Status of Next Generation Breast Cancer Tests
• Breast Cancer Early Detection and Screening Tests
• Breast Cancer Risk Tests
• Response to Chemotherapy, Recurrence Probability and Subtyping

Gynecologic Cancers

• Cervical Cancer
• Ovarian Cancer

Colorectal Cancer

• Conventional Colorectal Cancer Screening Tests
• Next Generation Colorectal Cancer Diagnostic Tests

Cancer Unknown Primary
Gastric Cancer
Kidney Cancer
Hematologic Tests: Leukemia and Myeloma
Liver Cancer
Lung Cancer
Hematologic Tests: Lymphomas
Melanoma
Pan-Cancer
Prostate Cancer
Thyroid Cancer

Chapter 8 Cancer Diagnostics Industries

Sequencing Instruments Industry
Long Read Sequencing Industry
Sequencing Informatics Industry
PCR Industry
Droplet Digital PCR Industry
CTC Capture and Detection Industry
Liquid Biopsy Assay Industry

Chapter 9 Industry Acquisitions and Strategic Alliances

Acquisitions
Strategic Alliances

Chapter 10 Cancer Diagnostics Markets

Forces Driving Growth
COVID-19 Impact on Cancer Diagnostic Markets
Cancer Markets
Market for Next Generation Cancer Diagnostics by Cancer Site

• Bladder Cancer
• Brain Cancer
• Breast Cancer
• Colorectal Cancer
• Gynecologic Cancers
• Cancer of Unknown Primary
• Gastric Cancer
• Hematologic Cancers
• Kidney Cancer
• Liver Cancer
• Lung Cancer
• Melanoma
• Pan-Cancer
• Pancreatic Cancer
• Prostate Cancer
• Thyroid Cancer

Market for Next Generation Cancer Diagnostics by Purpose of Analysis

• Screening/Early Detection Market
• Diagnosis Market
• Therapy Guidance Market
• Monitoring Market

Market for Next Generation Cancer Diagnostics by Test Platform

• PCR Test Platform
• NGS Test Platform
• Array/Microfluidics Test Platform
• Cells and/or EV Capture Test Platform
• Multiplex Conventional Test Platform

Market for Test Platforms by Cancer Site

• PCR Test Platform
• NGS Test Platform

Market by Diagnostic Segment

• Screening/Early Detection Market
• Diagnostics Market
• Monitoring Market
• Therapy Guidance Market
• Breast Cancer Diagnostics
• Colorectal Cancer Diagnostics
• Lung Cancer Diagnostics
• Pan-Cancer Diagnostics
• Prostate Cancer Diagnostics

Regional Market Analysis

Chapter 11 Patents

Circulating Tumor Cell Patents
Exosome Patents
Cell-free DNA (cfDNA) Patents
Biomarker-Related Patents
Patent Considerations: AI in Cancer Diagnostics

Chapter 12 Company Profiles

20/20 GENE SYSTEMS
ABBOTT LABORATORIES
ADAPTIVE BIOTECHNOLOGIES INC.
AGENDIA NV
AGILENT TECHNOLOGIES INC.
AKADEUM LIFE SCIENCES
AMBRY GENETICS
AMOY DIAGNOSTICS CO. LTD.
ANGLE PLC
APOCELL INC.
APOSTLE INC.
ARBOR VITA CORP.
ARCHER DX
AROCELL AB
ARUP LABORATORIES
ASPIRA LABS
ASURAGEN, INC.
ATILA BIOSYSTEMS
AVIVA BIOSCIENCES
BECTON, DICKINSON AND CO.
BGI SHENZHEN
BIOCARTIS NV
BIOCEPT INC.
BIODESIX INC.
BIOFIDELITY LTD.
BIOFLUIDICA INC.
BIOLIDICS LTD.
BIOLOGICAL DYNAMICS INC.
BIOPROGNOS SL
BIOTHERANOSTICS INC.
BIO-TECHNE CORP.
BLUESTAR GENOMICS INC.
CANCER GENETICS INC.
CARIS LIFE SCIENCES
CASTLE BIOSCIENCES INC.
CC DIAGNOSTICS BV
CELCUITY INC.
CELLMAX LIFE
CELLULAR ANALYTICS
CELL MICROSYSTEMS INC.
CELSEE DIAGNOSTICS
CHIP DIAGNOSTICS
CHRONIX BIOMEDICAL
CIRCULOGENE THERANOSTICS
CLINICAL GENOMICS TECHNOLOGIES
CODIAK BIOSCIENCES
DANAHER CORP.
DECIPHER BIOSCIENCES
DERMTECH
DIACARTA INC.
DNALYTICS
EPIGENOMICS AG
EPIC SCIENCES INC.
EXACT SCIENCES CORP.
FLUXION BIOSCIENCES INC.
FREENOME INC.
FULGENT GENETICS INC.
GENECENTRIC THERAPEUTICS
GENEDX INC.
GENERA BIOSYSTEMS
GENESEQ BIOSCIENCES PTY LTD.
GENETRON HEALTH TECHNOLOGIES INC.
GENEOSCOPY LLC
GENEXOSOME TECHNOLOGIES INC.
GRAIL INC.
GUARDANT HEALTH INC.
HOLOGIC INC.
HTG MOLECULAR DIAGNOSTICS INC.
IDL BIOTECH
ILLUMINA INC.
IMMUNIS AI
INCELLDX INC.
INIVATA LTD.
INTERPACE BIOSCIENCES INC.
INVITAE INC.
INVIVOSCRIBE INC.
JBS SCIENCE INC.
LABORATORY CORP. OF AMERICA INC.
LEXENT BIO INC.
LUCENCE DIAGNOSTICS PTE. LTD.
LUNGLIFE AI, INC.
MDNA LIFE SCIENCES INC.
MDXHEALTH INC.
MEDGENOME INC.
MENARINI SILICON BIOSYSTEMS SPA
MIRADX
MIR SCIENTIFIC
MUTANTDX
MY PERSONAL THERAPEUTICS LTD.
MYRIAD GENETICS INC.
NEOGENOMICS LABORATORIES
NEO NEW ONCOLOGY GMBH
NODEXUS
NOVIGENIX SA
NRICH DX
NUCLEIX
NUPROBE INC.
ONCIMMUNE HOLDINGS PLC
ONCOCYTE CORP.
ONCODNA S.A.
OPKO HEALTH
OXFORD GENE TECHNOLOGY
PACIFIC EDGE LTD.
PANGAEA LABORATORY
PANGAEA ONCOLOGY
PERSONAL GENOME DIAGNOSTICS INC.
POLYMEDCO, INC.
PREDICINE INC.
PROVISTA DIAGNOSTICS INC.
QIAGEN NV
QUANTUMDX
QUEST DIAGNOSTICS INC.
RARECYTE INC.
RESOLUTION BIOSCIENCE INC.
ROCHE HOLDING AG
SAGA DIAGNOSTICS AB
SANOMICS LTD.
SIENNA CANCER DIAGNOSTICS LTD.
SINGLERA GENOMICS INC.
SISTEMAS GENOMICOS
SKYLINEDX BV
STAGE ZERO LIFE SCIENCES
STRAND LIFE SCIENCES PVT., LTD.
SYSMEX INOSTICS GMBH
THERMO FISHER SCIENTIFIC INC.
THRIVE EARLIER DETECTION CORP.
TIZIANA LIFE SCIENCES PLC
VORTEX BIOSCIENCES
VERACYTE
VOLITIONRX
XING TECHNOLOGIES LLC
YIKON GENOMICS CO. LTD.

List of Tables

Summary Table : Global Market for Next Generation Cancer Diagnostics, by Cancer Site, Through 2025
Table 1 : Next Generation Cancer Diagnostics: Scope of Report
Table 2 : Large-Scale Initiatives: Cancer Diagnostics Industry
Table 3 : Global Market for Next Generation Cancer Diagnostics, by Technology Platform, Through 2025
Table 4 : Key Trends in the Market for Next Generation Cancer Diagnostics
Table 5 : Next Generation Cancer Diagnostics Industry Subsectors
Table 6 : Diagnostic Market Segments
Table 7 : Next Generation Diagnostics: Key Analysis Platforms
Table 8 : Analysis Platforms and Biomarker Types
Table 9 : DNA Microarray Technologies in Cancer Diagnostics
Table 10 : Design Features of Protein Microarray Technologies
Table 11 : Microfluidic LOAC Types Used in Cancer Diagnostics
Table 12 : Advanced Sequencing Technologies
Table 13 : Illumina Next Generation Sequencing Workflow
Table 14 : Thermo Fisher Scientific’s Next Generation Sequencing Workflow
Table 15 : Main Ingredients of PCR Technology
Table 16 : PCR Process
Table 17 : Advantages of Droplet Digital PCR for Single-Cell Analysis
Table 18 : Liquid Biopsy Biomarker Classes
Table 19 : Cancer Genomic Sequencing and Liquid Biopsy
Table 20 : Single-Cell Analysis to Identify Cancer Driver Mutations
Table 21 : Genomics-Based Oncology Workflow
Table 22 : Unique Challenges: CTC Capture and Analysis
Table 23 : CTC Workflow
Table 24 : Cell Differentiators
Table 25 : Cell Isolation Technologies
Table 26 : CTC Sample Preparation Technologies
Table 27 : Single-Cell Analysis Technologies
Table 28 : Estimated Annual Solid Biopsy Procedures, U.S., Selected Cancers
Table 29 : Main Risks of Needle-Based Tissue Biopsies
Table 30 : Factors in Tissue Biopsy
Table 31 : Approaches to Avatar-Driven Cancer Diagnostics
Table 32 : R&D: Next Generation Cancer Diagnostics
Table 33 : Single-Cell Core Research Facilities
Table 34 : Population Sequencing Projects
Table 35 : Bladder Cancer Diagnostic Tests, 2020
Table 36 : Brain Cancer: Next Generation Diagnostics Tests, 2020
Table 37 : Annual Breast Cancer Treatment Decisions, U.S., by Cancer Classification, 2020
Table 38 : Breast Cancer MDx Technology Platforms, 2020
Table 39 : Next Generation Breast Cancer Tests, 2020
Table 40 : Next Generation Human Papilloma Virus and Cervical Cancer Screening and Genotyping Tests, 2020
Table 41 : Ovarian Cancer Early Screening Formats, 2020
Table 42 : Ovarian Cancer: Next Generation Diagnostics Tests, 2020
Table 43 : CRC Screening Tests, 2020
Table 44 : Colorectal Cancer: Next Generation Diagnostic Tests, 2020
Table 45 : Cancer Unknown Primary: Next Generation Diagnostic Tests, 2020
Table 46 : Gastric Cancer: Next Generation Diagnostic Tests, 2020
Table 47 : Kidney Cancer: Next Generation Diagnostic Tests, 2020
Table 48 : Leukemia and Myeloma: Next Generation Diagnostic Tests, 2020
Table 49 : Liver Cancer: Next Generation Diagnostic Tests, 2020
Table 50 : Five-Year Survival Rates for Non-Small Cell Lung Cancer, 2020
Table 51 : Lung Cancer: Next Generation Diagnostic Tests, 2020
Table 52 : Lymphoma: Next Generation Diagnostic Tests, 2020
Table 53 : Melanoma: Next Generation Diagnostic Tests, 2020
Table 54 : Pan-Cancer: Next Generation Diagnostic Tests, 2020
Table 55 : Prostate Cancer Next Generation Diagnostic Tests, 2020
Table 56 : Thyroid Cancer: Next Generation Diagnostics Tests, 2020
Table 57 : Advanced Sequencing Industry Company Positioning
Table 58 : End-to-End Sequencing Approaches
Table 59 : Long-Read Sequencing Industry
Table 60 : Sequencing Informatics Industry
Table 61 : PCR Companies
Table 62 : Advantages of Droplet Digital PCR for Single-Cell Analysis
Table 63 : Digital PCR Liquid Biopsy Industry
Table 64 : CTC Separations Industry
Table 65 : Liquid Biopsy Assay Industry: Company Focus
Table 66 : NGS-Based Liquid Biopsy Market Differentiation
Table 67 : Cancer Diagnostics Industry Acquisitions, Jan. 2019-July 2020
Table 68 : Cancer Diagnostics Strategic Alliances, Jan. 2019-July 2020
Table 69 : Liquid Biopsy: Forces Driving Growth, 2020
Table 70 : Limitations of Solid Biopsy in Cancer Applications
Table 71 : Low-Frequency Mutation Detection
Table 72 : Global Market for Next Generation Cancer Diagnostics, by Cancer Site, Through 2025
Table 73 : Ovarian Cancer: Five-Year Survival Rate
Table 74 : NIH Liquid Biopsy Early Detection Initiative
Table 75 : Global Market for Next Generation Cancer Diagnostics, by Purpose of Analysis, Through 2025
Table 76 : MRI and Liquid Biopsy Methods
Table 77 : Early Detection: Tissue of Origin Approaches
Table 78 : Global Market for Next Generation Cancer Diagnostics, by Test Platform, Through 2025
Table 79 : FDA-Approved or CE-Marked Tests with Epigenetic Component
Table 80 : Global Market for PCR-Based Cancer Diagnostics, by Cancer Site, Through 2025
Table 81 : Global Market for NGS-Based Cancer Diagnostics, by Cancer Site, Through 2025
Table 82 : Global Market for Next Generation Cancer Screening/Early Detection, by Cancer Site, Through 2025
Table 83 : Global Market for Next Generation Cancer Diagnosis, by Cancer Site, Through 2025
Table 84 : Global Market for Next Generation Cancer Monitoring, by Cancer Site, Through 2025
Table 85 : Global Market for Next Generation Cancer Therapy Guidance, by Cancer Site, Through 2025
Table 86 : Global Market for Breast Cancer Diagnostics, by Analysis Method, Through 2025
Table 87 : Global Market for Colorectal Cancer Diagnostics, by Analysis Method, Through 2025
Table 88 : Global Market for Lung Cancer Diagnostics, by Analysis Method, Through 2025
Table 89 : Global Market for Pan-Cancer Diagnostics, by Analysis Method, Through 2025
Table 90 : Global Market for Prostate Cancer Diagnostics, by Analysis Method, Through 2025
Table 91 : Global Market for Next Generation Cancer Diagnostics, by Region, Through 2025
Table 92 : Patent Activity: Circulating Tumor Cells (CTCs), by Region, Jan. 2010–June 2020
Table 93 : Patent Activity: Exosomes, by Region, Jan. 2010-June 2020
Table 94 : Patent Activity: cfDNA, by Region, 2010–June 2020
Table 95 : Patent Activity: Cancer Biomarkers, by Region, Jan. 2010–June 2020

List of Figures

Summary Figure : Global Market for Next Generation Cancer Diagnostics, by Cancer Site, 2019-2025

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