Exosome Diagnostics and Therapeutics: Global Markets

Table of Contents

Chapter 1 Introduction

Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Intended Audience
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background

Exosome Definition and Nomenclature
Discovery of Exosomes

• Exosomes Biogenesis and Processing

Exosome Components

• DNA in Exosomes
• Proteins in Exosomes
• RNA in Exosomes

Isolation and Detection of Exosomes

• Isolation Techniques
• Exosome Detection

Bioinformatic Databases for Exosome Research and Product Development

• ExoCarta
• Vesiclepedia
• EVpedia

Exosome Function and Physiology

Chapter 4 Exosome Diagnostic Market

Exosomal Proteins as Diagnostic Biomarkers
Exosomal Nucleic Acids as Diagnostic Biomarkers
Cancer Diagnostics as Market Potential for Exosome-Based Diagnostic Product Development

• Prostate Cancer as Potential for Diagnostic Development in Exosome Sector
• Breast Cancer as Potential for Diagnostic Development in Exosome Sector
• Bladder Cancer as Potential for Diagnostic Development in Exosome Sector
• Ovarian Cancer as Potential for Diagnostic Development in Exosome Sector
• Lung Cancer as Potential for Diagnostic Development in the Exosome Sector

Liquid Biopsy as Potential for Diagnostics in Exosome Sector
Exosomal Proteins and Nucleic Acids as Cancer Biomarkers in Assay Development
CNS Disorders and Neurodegeneration Diseases as Market Potential for Exosome Diagnostics Product Development
Infectious Diseases as Market Potential for Exosome Diagnostic Product Development
Cardiovascular Diseases as Market Potential for Exosome Diagnostic Product Development
Prenatal Testing as Market Potential for Exosome Diagnostic Product Development
Organ Transplantation as Market Potential for Exosome Diagnostic Product Development
Market Participants in Exosome-Based Diagnostics Sector

• Amarantus BioScience
• Caris Life Sciences
• Exosome Diagnostics
• Exosome Sciences/Aethlon Medical
• Exosomics Siena SPA
• NanoSomiX
• NX Pharmagen
• NX Prenatal
• Orion Pharma
• Sistemic
• Ymir Genomics
• Additional Exosome-Based Diagnostic Market Participants

Evaluation of Current Diagnostics Sector in Exosome Market

Chapter 5 Exosome Therapeutic Market

Intrinsic Therapeutic Activity of Exosomes
Immunological Compatibility
Cargo Capabilities
Generation of Exosome-Mediated Therapeutics

• Exosome Isolation and Purification from Biofluids or Cell Culture
• Engineering Exosomes as Therapeutic Delivery Vehicles

Targeting Exosomes to Specific Recipient Cells
Designing Exosomes as a Synthetic Vector
Market Potential for Exosome Therapeutics
Market Participants in Exosome-Based Therapeutics Sector

• Aegle Therapeutics
• Aethlon Medical
• Anjarium Biosciences
• BioRegenerative Sciences
• Capricor Therapeutics
• The Cell Factory
• Codiak BioSciences
• Creative Medical Technology Holdings (CMTH)
• DreiRosen Pharma
• Evox Therapeutics
• ExoCoBio
• ExoCyte Therapeutics
• Exogenus Therapeutics
• Exopharm
• Exotech Bio
• Exovita Biosciences
• Intrexon Corp.
• Kimera Labs
• MDimune
• MolecuVax
• Panacea Pharmaceuticals Inc.
• Paradigm Pharmaceuticals
• ReCyte
• Regeneus
• ReNeuron
• Therapeutic Solutions International
• Unicyte AG
• Additional Pharma and Biotech Companies with Potential Exosome Research Projects

Clinical Trials as Indicators for Exosome Market Development
Evaluation of Current Therapeutics Sector in Exosome Market

Chapter 6 Exosome Reagents and Research Tools Market

Market Overview

• Isolation Methodologies and Reagents for Exosome
• Detection Methodologies and Reagents for Exosome Research
• Characterization Methods and Reagents for Exosome Research
• Engineering Methods and Reagents for Exosome Research
• Additional Products and Reagents for Exosome Research

Market Participants for Reagents and Tools for Exosome Research

• 101Bio
• AMSBIO
• Cell Guidance Systems
• Ciloa
• Evomic Science
• Excytex
• ExoCan
• HansaBioMed (Lonza)
• IzonScience
• NanoSight (Malvern Instruments)
• Nanoview Biosciences
• System Biosciences (SBI)
• Additional Market Participants for Reagents and Tools for Exosome Research

Evaluation of Current Tools and Reagents in the Exosome Market

Chapter 7 Global Exosome Therapeutic and Diagnostic Market by End User

Cancer Institutes
Hospital and Diagnostic Centers

• Exosomal Proteins as Diagnostic Biomarkers
• Exosome Nucleic Acids as Diagnostics Biomarkers
• Exosomes: Novel Biomarkers for Clinical Diagnosis

Others: Pharmaceutical and Life Science Industries and Academic Institutes

Chapter 8 Market Breakdown by Region

North America
Europe
Asia-Pacific
RoW

Chapter 9 Impact of Exosome Research on Specific Biopharmaceutical Market

Exosome Research Impact on Biomarker and Diagnostic Industry
Exosome Research Impact on MicroRNA Market
Exosome Research Impact on the Liquid Biopsy Market
Exosome Research Impact on Stem Cell Technologies Market
Exosome Research Impact on Prenatal Diagnostic Market
Exosome Research Impact on Agriculture and Food Industry
Exosome Research, Microfluidics and Nanotechnology
Exosome Research Impact on Skincare Industry

Chapter 10 Patent Analysis

U.S. Patent Analysis
European Patent Analysis
Japan Patent Analysis

Chapter 11 Marker Summary

Chapter 12 Company Profiles

CODIAK BIOSCIENCES
EVOX THERAPEUTICS LTD.
EXOSOME DIAGNOSTICS INC.
HANSABIOMED LIFE SCIENCES LTD. (LONZA)
NANOSOMIX INC.
SYSTEM BIOSCIENCES (SBI)

List of Tables

Summary Table : Global Market for Exosome Diagnostics and Therapeutics, by Product, Through 2023
Table 1 : Nomenclature of Exosome Particles
Table 2 : Publication Trend on the Subject of Exosome, 2003-2017
Table 3 : Molecules Involved in Exosome Biogenesis and/or Release
Table 4 : Steps in Exosome Biogenesis and Processing
Table 5 : Proteins Essential in Exosome Biogenesis and Processing
Table 6 : Proteins Found in Exosomes
Table 7 : MicroRNA in Different Bodily Fluids
Table 8 : Methods for Exosome Isolation
Table 9 : Distribution of Exosomes Isolation Procedures in the Studies Cataloged in ExoCarta
Table 10 : Statistics of Data Cataloged in ExoCarta, 2012 and 2017
Table 11 : Statistics of Data Cataloged in Vesiclepedia, 2012 and 2017
Table 12 : Statistics of Data Cataloged in EVpedia, 2018
Table 13 : Comparison of Databases for Exosome Studies
Table 14 : Examples of Exosomal Proteins for Clinical Diagnostic Applications
Table 15 : Examples of Exosomal MicroRNA for Clinical Diagnostic Applications
Table 16 : Characteristic Exosomal MicroRNAs in Various Biological Fluids
Table 17 : Expression Status of MicroRNAs as the Exosomal Cargo in Different Cancer Types
Table 18 : Statistics for Prostate Cancer, 2017
Table 19 : Studies of microRNAs in PCa Patients
Table 20 : Global Market for Prostate Cancer Diagnostics and Related Cost, 2017 and 2022
Table 21 : Statistics for Breast Cancer, 2017
Table 22 : Global Market for Breast Cancer Diagnostics, Through 2023
Table 23 : Statistics for Bladder Cancer, 2017
Table 24 : Functions of Exosomal Noncoding RNAs and Proteins in Tumor Metastasis and Invasion
Table 25 : Global Market for Bladder Cancer Diagnostics, 2017
Table 26 : Statistics for Ovarian Cancer, 2017
Table 27 : MicroRNA Content of Ovarian Cancer-Derived Exosomes
Table 28 : Global Market for Ovarian Cancer Diagnostics, 2017
Table 29 : Summary of the Predictive Exosomal Components Described Until Now, Including Utility and Values Represented, by Sensitivity
Table 30 : Statistics for Lung Cancer, 2017
Table 31 : Global Market for Lung Cancer Diagnostics, 2017
Table 32 : Liquid vs. Tissue Biopsy
Table 33 : Global Market for Liquid Biopsy Including Research Tools, Services and Diagnostics, Through 2022
Table 34 : Exosomal Protein Biomarkers from Bodily Fluids of Patients in Pre-Clinical and Clinical Studies
Table 35 : Exosomal Nucleic Acid Biomarkers in Pre-Clinical and Clinical Studies
Table 36 : U.S. Statistics for Alzheimer's, 2017
Table 37 : Global Market for Alzheimer's Disease Therapeutics and Diagnostics, Through 2023
Table 38 : Global Statistics for Hepatitis C Infection, 2015
Table 39 : Estimated Actual New Cases of HAV (Range)
Table 40 : Global Market for Hepatitis C Diagnostics, 2017
Table 41 : U.S. Statistics for Cardiovascular Diseases, 2017
Table 42 : Global Market for Cardiovascular Diagnostics, 2017
Table 43 : Global Market for Prenatal Diagnostics, Predictive Tests and Neonatal Monitoring, Through 2023
Table 44 : Global Market for Organ and Tissue Transplantation Products and Devices, Through 2020
Table 45 : Comparison of Exosome Diagnostics' Approach to Other Liquid Biopsy Platforms
Table 46 : Main Market Participants in Exosome-Based Diagnostics Sector
Table 47 : Global Market for Exosome Diagnostics, Through 2023
Table 48 : Examples of Studies Using Extracellular Vesicles as Drug Delivery Vehicles
Table 49 : Examples of Engineering Exosome for Cargo Delivery
Table 50 : Type of Cargo and Loading Method
Table 51 : Examples of Physiological Effect of Exosome Delivery
Table 52 : Sales of Top Five Vaccine Providers, 2016
Table 53 : Age Groups Suffering from Alzheimer's Disease in United States, 2017
Table 54 : Global Prevalence of Tuberculosis, 2010-2016
Table 55 : Global Prevalence of Cancer, 2010-2016
Table 56 : U.S. Statistics for Burn Injuries
Table 57 : U.S. Statistics for Pressure Ulcer
Table 58 : Global Market for Aethlon Medical, 2012-2017
Table 59 : Global Market Revenue, Cost and Profits for Capricor Therapeutics, 2012-2017
Table 60 : Main Market Participants in Exosome-based Therapeutics Sector
Table 61 : Examples of Clinical Trials Related to Exosome Research
Table 62 : Examples of Financing for Exosome-based Therapeutics Companies till 2017
Table 63 : Global Market for Exosome Therapeutics, Through 2023
Table 64 : Main Steps in Exosome Research Approach
Table 65 : Examples of Commercial Kits and Reagents for Exosome Isolation
Table 66 : Frequency of Use for Each Isolation Technique for Exosome Purification
Table 67 : Range of Model Options with Zetasizer Nano ZS Instrument
Table 68 : Examples of Detection Assay
Table 69 : Examples of Antibody Providers for Exosome Research
Table 70 : Commercial RNA Extraction Kits
Table 71 : Percentage of Use of Characterization Techniques for Exosome Sample
Table 72 : Examples of Purified Exosomes Commercial Products
Table 73 : Main Market Participants in Exosome Research Tools and Reagents
Table 74 : Global Market for Exosome Research Tools and Reagents, Through 2023
Table 75 : Global Market for Exosome Therapeutics and Diagnostics, by End User, Through 2023
Table 76 : Global Market for Exosomes in Cancer Institute, by Region, Through 2023
Table 77 : Number of People with Cancer Globally, 2005-2016
Table 78 : Studies Employing Exosomes without Genetic Modification in Cancer Treatment
Table 79 : In Vivo and In Vitro Studies Using Modified Exosomes for Cancer Therapy
Table 80 : Global Market for Exosomes in Hospitals and Diagnostics Centers, by Region, Through 2023
Table 81 : Exosome Protein in Clinical Diagnostics Applications
Table 82 : Exosomes: Novel Biomarkers for Clinical Diagnosis
Table 83 : Global Market for Exosome in Other End User Segment, by Region, Through 2023
Table 84 : Global Market for Exosome Diagnostics and Therapeutics, by Region, Through 2023
Table 85 : Leading Cause of Deaths Related to Cancer in UAE, by Cancer Type, 2015
Table 86 : Leading Causes of Death in Argentina and Percent Change, 2005-2016
Table 87 : Examples of Protein Markers in Exosomes and Their Related Pathologies
Table 88 : Examples of MicroRNA Markers in Exosomes and Their Related Pathologies
Table 89 : Comparison between Liquid Biopsy and Tissue Biopsy
Table 90 : Global Market for Prenatal Diagnostics, Predictive Tests and Neonatal Monitoring, Through 2023
Table 91 : U.S. Patents on Exosome Diagnostics and Therapeutics, January 2015-October 2018
Table 92 : European Patents on Exosome Diagnostics and Therapeutics, January 2015-October 2018
Table 93 : Japanese Patents on Exosome Diagnostics and Therapeutics, January 2015-October 2018
Table 94 : Global Market for Exosome Diagnostics and Therapeutics, by Application, Through 2023
Table 95 : Main Market Participants in Exosome Market
Table 96 : Product Portfolio: Codiak Biosciences
Table 97 : Recent Development: Codiak Biosciences 2015 to June 2018
Table 98 : Product Portfolio: EVOX Therapeutics Ltd.
Table 99 : Recent Development: EVOX Therapeutics Ltd., 2015 to June 2018
Table 100 : Product Portfolio: Exosome Diagnostics Inc.
Table 101 : Recent Developments: Exosome Diagnostics Inc., 2016-2018
Table 102 : Product Portfolio: HansaBioMed Life Sciences Ltd. (Lonza)
Table 103 : Recent Developments: HansaBioMed Life Sciences Ltd. (Lonza), 2017
Table 104 : Product Portfolio: Nanosomix Inc.
Table 105 : Product Portfolio: System Biosciences (SBI)

List of Figures

Summary Figure : Global Market for Exosome Diagnostics and Therapeutics, by Product, 2017-2023
Figure 1 : Publication Trend on the Subject of Exosome, 2003-2017
Figure 2 : Differential Centrifugation Process
Figure 3 : Ciliated Porous Device Designed to Isolate Exosomes, by Filtration
Figure 4 : Sieving Models for Exosome Filtration
Figure 5 : Workflow of Mirna-Based Therapeutic Delivery Using Exosomes to Treat Alcoholic Liver Disease
Figure 6 : Global Market for Exosome Diagnostics, 2017-2023
Figure 7 : Age Groups Suffering from Alzheimer's Disease in the United States, 2017
Figure 8 : Global Prevalence of Tuberculosis, 2010-2016
Figure 9 : Global Prevalence of Cancer, 2010-2016
Figure 10 : Global Market for Exosome Therapeutics, 2017-2023
Figure 11 : Global Market for Exosome Research Tools and Reagents, 2016-2023
Figure 12 : Number of People with Cancer Globally, 2005-2016
Figure 13 : Global Incidence of Patients with Chronic Diseases, 2005-2030
Figure 14 : Global Market for Exosome Diagnostics and Therapeutics, by Application, 2017-2023"

Report Scope:

This report represents a current and important business tool to evaluate new commercial opportunities in the exosome diagnostic, therapeutic and research tool markets. The geographic scope of this study covers the U.S. and companies worldwide. This market is complex and consists of a number of different sectors, each affected differently by scientific and technological development. The report identifies the main positive and negative factors in each sector and forecasts further trends and product and assay development in every category of this industry.

Report Includes:

- 106 tables
- An overview of the global market for exosome diagnostics and therapeutics
- Analyses of global market trends, with data from 2017, 2018, and projections of compound annual growth rates (CAGRs) through 2023
- Description of immunological compatibility, cargo capabilities and other intrinsic therapeutic activities of exosomes
- Details of isolation and detection techniques and description of reagents and tools used for exosome research
- Evaluation of exosomal proteins and nucleic acids as diagnostic biomarkers and discussion of their impact on microRNA, liquid biopsy and stem cell research industry
- Information on bioinformatics databases for exosome research and product development, including as ExoCarta, Vesiclopedia and EVpedia
- Company profiles of the prominent players, including Codiak BioSciences, Evox Therapeutics Ltd., Exosome Diagnostics Inc., HansaBioMed Life Sciences Ltd. (Lonza), NonoSomiX Inc., and System Biosciences (SBI)"

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