In Vitro Toxicity Testing: Technologies and Global Markets

Table of Contents

Chapter 1 Introduction

Study Goals and Objectives
Reasons for Doing This Study
Intended Audience
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background

Introduction
Regulatory Framework and Programs

• European Union
• India
• Regulatory Programs

Key Market Growth Factors

• Replacement of In Vivo Models, by In Vitro Models
• In Vitro Toxicity in the Drug Discovery Process
• CROs Gaining Popularity
• Application of High-Throughput Screening in Toxicology

Opportunities

• Extensive Funding, by Research Institutes on Toxicology
• Paradigm Shift in Toxicity Testing in the 21st Century

Limitations and Challenges

• Expensive Equipment Used in Toxicology

Chapter 4 Market Breakdown by Toxicity Endpoints and Tests

ADME

• In Vitro Metabolism Offerings
• Metabolism Reaction Phenotyping for Genetic Polymorphisms

Skin Irritation, Corrosion and Sensitization
Genotoxicity Testing

• In Vitro Micronucleus Test (MNT)

Cytotoxicity Testing

• Use of Cytotoxicity Assays for Acute Toxicity Testing
• Example of Commercially Available Cytotoxicity Assay Kit

Ocular Toxicity
Organ Toxicity
Phototoxicity Testing
Dermal Toxicity
Carcinogenicity

• The AMES Test

Neurotoxicity
Development and Reproductive Toxicity (DART)
Other Toxicity Endpoints and Tests

Chapter 5 Market Breakdown by End-User Industry

Pharmaceutical and Biotechnology Companies
Healthcare (Diagnosis)
Food and Beverage Industry
Chemical Industry

• Challenges for Chemical Companies: Depth and Breadth

Personal Care Products (Cosmetics)
Contract Research Organizations
Research Institutes

• Center for Alternatives to Animal Testing (CAAT)
• European Union Reference Laboratory for Alternatives to Animal Testing (EURL)
• The Hamner Institutes for Health Sciences

Chapter 6 Market Breakdown by Tool/Technology

Transcriptomics

• Tools Used in Transcriptomics

Proteomics

• Proteomics Tools

Metabolomics

• Collaboration for Establishing Metabolomics Lab
• Metabolomics Tools

Cellomics or Cytomics

Chapter 7 Market Breakdown by Component

Assays

• Companies Strategies for the Development of New, and Expansion of Existing Products:
• Assay Kits for High-Content Screening
• Cell-Based Assays: Overview and Newer Developments
• Components of Cell-Based Assay Systems

Equipment
Reagents and Kits

• New Reagents in the Market

Software and Analytics

• Trace Finder Software, by Thermo Fisher Scientific, Inc.

Services

• ADME Screening

Chapter 8 Market Breakdown by Region

North America

• United States
• Recent Developments in the Region
• Canada

Europe

• United Kingdom
• Germany
• France
• Spain
• Italy
• Rest of Europe

Asia-Pacific

• China
• Japan
• India
• Rest of Asia-Pacific

Rest of the World

• Middle East
• Africa
• Latin America

Chapter 9 Patent Review/ New Developments

Biomarkers for In Vitro Toxicology

• Uses of In Vitro Biomarkers
• In Vitro Biomarkers: Future Prospects
• Types of Biomarkers

Competitive Landscape

• Key Companies
• Key Market Player Strategies

Patent Analysis

Chapter 10 Company Profiles

ABBOTT LABORATORIES, INC.

• Business Overview

ACEA BIOSCIENCES, INC.

• Business Overview

AGILENT TECHNOLOGIES, INC.

• Business Overview

ALBANY MOLECULAR RESEARCH, INC.

• Business Overview

APTUIT, INC.

• Business Overview

BIOGNOSYS AG

• Business Overview

BIORELIANCE

• Business Overview

BIOVIA
CELLULAR DYNAMICS INTERNATIONAL, INC.

• Business Overview

CHANTEST

• Business Overview

CHARLES RIVER LABORATORIES

• Business Overview

COVANCE, INC.

• Business Overview

CYPROTEX PLC

• Business Overview

DRIK LLC

• Business Overview

ENZO LIFE SCIENCES, INC.

• Business Overview

ESSEN BIOSCIENCE, INC.

• Business Overview

EUROFINS SCIENTIFIC SE

• Business Overview
• Products Offered

EVOTEC AG

• Business Overview

GE HEALTHCARE LIFE SCIENCES

• Business Overview

GENEDATA

• Business Overview

GENTRONIX LTD.

• Business Overview

HUREL CORP.

• Business Overview

IMQUEST BIOSCIENCES, INC.

• Business Overview

IMSTAR SA

• Business Overview

INSPHERO AG

• Business Overview

KIYATEC, INC.

• Business Overview

LONZA GROUP LTD.

• Business Overview
• Products Offered

METABOLON, INC.

• Business Overview

MOLECULAR DEVICES LLC

• Business Overview

PERKINELMER, INC.

• Business Overview

PROMEGA CORP.

• Business Overview
• Products Offered

QIAGEN NV

• Business Overview
• Products Offered

SGS-SA

• Business Overview

STEMINA BIOMARKER DISCOVERY, INC.

• Business Overview

SYNVIVO, INC.

• Business Overview

THERMO FISHER SCIENTIFIC, INC.

• Business Overview

VALA SCIENCES, INC.

• Business Overview

VISTAGEN THERAPEUTICS, INC.

• Business Overview

XENOMETRIX AG

• Business Overview

List of Tables

Summary Table : Global Market for In Vitro Toxicity Testing, by Region, Through 2023
Table 1 : Research Institutes/Organizations that Offer In Vitro Testing and Other Services
Table 2 : Instruments Used in In Vitro Toxicology Testing, 2017
Table 3 : Global Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint and Test, Through 2023
Table 4 : ADME In Vitro Toxicity Products
Table 5 : Global Market for ADME Testing Technologies, by Region, Through 2023
Table 6 : Global Market for Skin Irritation, Corrosion and Sensitization Testing Technologies, by Region, Through 2023
Table 7 : Genotoxicity Testing Products
Table 8 : Global Market for Genotoxicity Testing Technologies, by Region, Through 2023
Table 9 : Global Market for Cytotoxicity Testing Technologies, by Region, Through 2023
Table 10 : Global Market for Ocular Toxicity Testing Technologies, by Region, Through 2023
Table 11 : Global Market for Organ Toxicity Testing Technologies, by Region, Through 2023
Table 12 : Validated Non-animal Methods
Table 13 : Global Market for Phototoxicity Testing Technologies, by Region, Through 2023
Table 14 : Global Market for Dermal Toxicity Testing Technologies, by Region, Through 2023
Table 15 : OECD TGs for In Vitro Genotoxicity and Mutagenicity Testing
Table 16 : Global Market for Carcinogenicity Testing Technologies, by Region, Through 2023
Table 17 : General Endpoints Used for In Vitro Neurotoxicity Testing
Table 18 : Global Market for Neurotoxicity Testing Technologies, by Region, Through 2023
Table 19 : Global Market for DART Testing Technologies, by Region, Through 2023
Table 20 : Global Market for Other Toxicity Endpoints and Tests Technologies, by Region, Through 2023
Table 21 : Global Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 22 : Global Market for Pharmaceutical and Biotechnology End-User Industry, by Region, Through 2023
Table 23 : Global Market for Healthcare End-User Industry, by Region, Through 2023
Table 24 : Global Market for Food and Beverage End-User Industry, by Region, Through 2023
Table 25 : Global Market for Chemical End-User Industry, by Region, Through 2023
Table 26 : Chemical Companies that Provide Vitro Toxicology Services
Table 27 : Global Market for Personal Care Products End-User Industry, by Region, Through 2023
Table 28 : CROs Providing In Vitro Toxicology Services
Table 29 : Global Market for CROs End-User Industries, by Region, Through 2023
Table 30 : Global Market for Research Institutes End-User Industries, by Region, Through 2023
Table 31 : Research Institutes Providing In Vitro Toxicology Tests
Table 32 : Global Market for In Vitro Toxicology Testing Technologies, by Tool/Technology, Through 2023
Table 33 : Global Market for Transcriptomics, by Region, Through 2023
Table 34 : Global Market for Proteomics, by Region, Through 2023
Table 35 : Global Market for Metabolomics, by Region, Through 2023
Table 36 : Common Analytical Platforms Used in Metabolomics
Table 37 : Global Market for Cellomics, by Region, Through 2023
Table 38 : Global Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 39 : Global Market for Assays, by Region, Through 2023
Table 40 : Global Market for Equipment, by Region, Through 2023
Table 41 : Global Market for Reagents and Kits, by Region, Through 2023
Table 42 : Specifications of HCS LIVE⁄DEAD Green Kit
Table 43 : Global Market for Software and Analytics, by Region, Through 2023
Table 44 : Global Market for Services, by Region, Through 2023
Table 45 : North American Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 46 : North American Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 47 : North American Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 48 : North American Market for In Vitro Toxicity Testing Technologies, by Tools/Technology, Through 2023
Table 49 : North American Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 50 : In Vitro Services Offered by Nucro-Technics
Table 51 : Tracking System for Alternative Test Methods, Review (TSAR), 2018
Table 52 : European Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 53 : European Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 54 : European Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 55 : European Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 56 : European Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 57 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 58 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 59 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 60 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 61 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 62 : Top 20 R&D Pharmaceutical Companies in China
Table 63 : Rest of the World Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 64 : Rest of the World Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 65 : Rest of the World Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 66 : Rest of the World Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 67 : Number of Patents, by Category in Different Countries, January 2016 to July 2018
Table 68 : Patents, by Key Players, January 2016 to July 2018
Table 69 : List of Patents Analyzed, January 2016 to July 2018"

List of Figures

Summary Figure : Global Market for In Vitro Toxicity Testing, by Region, 2017-2023
Figure 1 : Timeline of Animal Testing Ban in India
Figure 2 : Regulations timeline for Cosmetic Testing on Animals
Figure 3 : Comparison Between In Vivo and In Vitro Toxicity
Figure 4 : Discovery Toxicology
Figure 5 : Merck KGaA Toxicology Services
Figure 6 : Global Per Capita Healthcare Expenditure, by Country, 2016
Figure 7 : In Vitro Toolbox for Acute Inhalation Toxicity
Figure 8 : Features of ToxiScreen
Figure 9 : Drug Discovery Process
Figure 10 : Use of Metabolomics Toxicology
Figure 11 : Types of Toxicity Studies
Figure 12 : Features of Thiol Tracker Violet
Figure 13 : Features of TraceFinder Software
Figure 14 : Healthcare Expenditures for R&D, by State and Performer, FY 2016
Figure 15 : Total Health Expenditures, by Source of Finance, 2016
Figure 16 : Healthcare Expenditure as a Share of GDP, by Region/Country, 2015
Figure 17 : E.U. Innovation Funding, by Horizon 2020, by Projects, 2014-2022
Figure 18 : Biotech Funding in the U.K., 2017
Figure 19 : Active Market Players in the U.K.
Figure 20 : Germany Health Spending, 2013-2016
Figure 21 : Research and Development Funding in Health Research and Health Industry, 2016-2017
Figure 22 : Chinese Pharmaceutical Sales, 2015 and 2020
Figure 23 : List of Programs and Description
Figure 24 : Japan’s Pharmaceutical R&D Expenditure, 1995-2015
Figure 25 : Indian’s Pharmaceutical Exports, 2014-2018
Figure 26 : Thermo Fisher Scientific, Inc.: Revenue Share, by Segment, 2017
Figure 27 : Thermo Fisher Scientific, Inc.: Share of Revenue Generation, by Region, 2017"

 

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