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細胞ベースアッセイ:技術および世界市場

Cell-based Assays: Technologies and Global Markets

出版元:BCC ResearchLinkIcon出版元について
発行年:2018年11月
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【レポート紹介】
細胞ベースアッセイの世界市場規模は2018年で推計201億ドル、この先2023年では327億ドルに達すると予測されます。当レポートでは、細胞ベースアッセイの市場概要、現在の技術、商業化、アッセイ/インストゥルメント市場(各種セグメント別予測)、地域別市場、主要企業プロフィールなどを盛り込み、概略以下の構成でお届けいたします。

【レポート構成概要】
◆イントロダクション
・調査目的
・調査対象
・調査手法

◆サマリーと調査ハイライト

◆細胞ベースアッセイ市場:市場概要
・創薬
・ハイコンテントスクリーニング
・データ分析
・概要
・創薬ツール
・細胞ベースアッセイの発展

◆創薬アッセイ
・ADME/Toxスクリーニングにおける細胞ベースアプローチ

◆細胞ベースアッセイ市場:現在の技術
・細胞ベースアッセイ発展における要因
・レポーター遺伝子技術
・タンパク質間相互作用研究
・細胞ベースタンパクフラグメント相補性アッセイ

◆細胞ベースアッセイの商業化
・細胞ベースアッセイの役割

◆細胞ベースアッセイ及びインストゥルメント市場
・細胞生物学試薬/ツール
・ハイスループットスクリーニング(HTS)
・創薬技術
・ライフサイエンス研究におけるツール/試薬
・細胞培養
・細胞培養試薬
・米国市場、細胞培養
・三次元細胞培養
・細胞ベースアッセイ
・基礎研究における細胞ベースアッセイ
・創薬における細胞ベースアッセイ
・ADMEアッセイ
・ハイコンテントスクリーニング用機器
(※上記項目につき市場予測-2023年掲載)

◆世界市場
・世界市場概要
・北米市場
- 米国
・欧州市場
・新興国における創薬
・細胞ベースアッセイの進化

◆細胞ベースアッセイ市場:主要企業プロフィール
・ACEA BIOSCIENCES
・BD BIOSCIENCES
・BECKMAN COULTER
・CELLULAR DYNAMICS INTERNATIONAL
・CALIPER LIFE SCIENCES
・CELSIS IN VITRO TECHNOLOGIES (CELSIS IVT)
・CISBIO BIOASSAYS
・DISCOVERX CORP.
・EMD MILLIPORE
・ENZO LIFE SCIENCES
・ENDONOVO THERAPEUTICS
・EVOTEC AG
・GE HEALTHCARE
・HEMOGENIX
・LIFE TECHNOLOGIES
・LONZA
・MOLECULAR DEVICES (DANAHER)
・ONCOLMMUNIN
・ORIGENE TECHNOLOGIES
・PERKINELMER
・PROMEGA CORP.
・ROCHE GROUP
・STEMCELLS INC.
・THERMO FISHER SCIENTIFIC
・TTP LABTECH
・VIVO BIOSCIENCES
・VITRO BIOPHARMA

◆細胞ベースアッセイ市場:法的側面
・知的財産権の状況

(全242貢)


【レポート詳細目次、データ項目一覧は当ページ下を参照ください】

英文詳細目次(table of contents)

【原文詳細目次】

Cell-based Assays: Technologies and Global Markets

Table of Contents

Chapter 1 Introduction

Study Goals and Objectives
Reasons for Doing This Study
Scope of the Report
Intended Audience
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Overview

Introduction
Drug Discovery
High-content Screening
Data Analysis
Overview: Cell-based Assay
Tools for Drug Discovery

  • High-content Screening
  • Cell-based Screening
  • Proliferation Assays
  • Proof of Concept for Cell-based Assays
  • Cell-based Assays and Technology Trends

Advancements in Cell-based Assays

  • Novel Cell-based Assay Using Organoids, Scaffolds/Hydrogels and Organs-on-a-Chip
  • Spheroids for Drug Development
  • Label-free Cell-based Assay Technology Using Biolayer Interferometry
  • Lineage Sequencing for Mutational Analysis and Cancer-based Studies
  • Evaluation of Hantavirus Replication Using In-cell Western Assay
  • Quantitative Cell-based Assay Using a High-content Analysis Platform
  • High-throughput Single-cell Transcriptome Sequencing
  • Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy
  • G Protein-coupled Receptors
  • Luciferase-based High-throughput Screening Assay
  • Functionally Relevant Morphological Profiling for Mesenchymal Stromal Cells

Chapter 4 Assays for Drug Discovery

Cell-based Approaches for ADME/Tox Screening

  • Market Opportunities
  • ADME and Toxicity Screening
  • Multiplexed Cell-based Assays
  • High-throughput Imaging-based Platform for Cell-based Assays
  • Cell Assays in Today's Drug Discovery Process
  • Label-free Cellular Assays: The Relevant Future of Drug Discovery

Conclusion

Chapter 5 Cell-based Assays: Current Technologies

Factors in Cell-based Assay Development
Reporter Gene Technology
Cell-based Assays for Studying Protein-Protein Interactions
Cell-based Protein-fragment Complementation Assays
Measuring Calcium Signaling
Cell-based Label-free Approaches
Automation and Miniaturization
Cell Patterning
Cell-based Assays and Physiological Relevance
Cell-based Assays and Multiplexing

  • Developing Reporter Assays
  • Reporter Assays and Multiplexing

Ultrahigh-throughput Screening
Development of the PathHunter Assay
High-content Screening Technology

  • Imaging Cells for Cell-based Assays
  • Microscopic Visualization of Cells
  • Quantum Dots
  • Label-free Imaging

Investigational New Studies in Drug Development

  • Role of ADME in Drug Design

Prodrug Strategies
Molecular Modeling
Summary

  • Limitations of Cell-based Assays in the Risk Assessment Process
  • Bottlenecks in Cell-based Screening
  • Methods to Improve Throughput in Cell-based Assays

New Technologies

  • DataChip
  • BIND Technology
  • Miniaturization of Biological Assays
  • Microfluidic Cell Culture Systems for Drug Research

Conclusion

Chapter 6 Commercialization of Cell-based Assays

Role of Cell-based Assays

  • Drug Discovery and Cell-based Assays
  • Opportunities for Market Adoption
  • Measuring Cell Proliferation
  • Companies Offering Cell Proliferation Assays
  • Move Toward Therapies with Stem and Immune Cells
  • Cell-based Screening Assays
  • Orphan Receptors

Summary

Chapter 7 Global Cell-based Assay and Instrumentation Market

Current Market Overview
Cell-based Assays
Cell-based Assay Market

  • Market Dynamics
  • Market Drivers
  • Cell-based Assays for Preclinical Development

Cell Biology Reagents
High-throughput Screening

  • Advantages of HTS Assays
  • Major Drivers

Drug Discovery Technology Market
Market for Life Sciences Tools and Reagents
Cell Culture Market

  • Cell Culture Reagent Market

Global Market for Cell Culture Reagents

  • Three-dimensional Cell Culture Market

Cell-based Assay Market Growth

  • Market Demand

Cell-based Assays: Basic Research
Market for Cellular Assays in Basic Research

  • Cell Proliferation Fluorescence Assay
  • In Vitro Toxicity Testing
  • In Vitro Skin Irritation Testing

ADME and Toxicology Market

  • In Vitro Predictive Toxicology

Cell-based Assays for Drug Discovery
ADME Toxicology Testing Market

  • DiscoverX
  • ADME Tools and Technologies
  • ADME Studies for FDA Submissions
  • Market Players
  • New Developments
  • In Vitro Inflammation Models
  • Multiplex Assays for GPCR Signaling

Types of Cell-based Assays

  • HCS Market Drivers
  • High-Content Screening Kits

High-Content Screening Instrumentation Market

  • Flow Cytometers

Label-free Detection Market
Microplate Instrumentation and Supplies
Challenges of Cell-based Assays
Future of Cell-based Assays
Cell-based Assays for Research Purposes

  • G Protein-Coupled Receptors

GPCRs: A Potent Class of Drug Targets

  • GPCR Drugs
  • Developments

Cell-based Assays: Screening Ion Channels
Label-free Detection
Companies

  • Thermo Fisher
  • CellSensor
  • LanthaScreen
  • Molecular Devices

Conclusion

Chapter 8 Global Markets

Global Market Overview
Global Market for Cell-based Assays

  • Cell-based Assays in Leading Emerging Markets

Summary
North American Market

  • U.S. Market

European Market
Drug Discovery in Emerging Economies

  • Drug Discovery in India and China

Advances in Cell-based Assays

  • Contract Research Organizations and Cell-based Assays
  • Outlook

Chapter 9 Company Profiles

ACEA BIOSCIENCES
BD BIOSCIENCES
BECKMAN COULTER
CELLULAR DYNAMICS INTERNATIONAL
CALIPER LIFE SCIENCES
CELSIS IN VITRO TECHNOLOGIES (CELSIS IVT)
CISBIO BIOASSAYS
DISCOVERX CORP.
EMD MILLIPORE
ENZO LIFE SCIENCES
ENDONOVO THERAPEUTICS
EVOTEC AG
GE HEALTHCARE
HEMOGENIX
LIFE TECHNOLOGIES
LONZA
MOLECULAR DEVICES (DANAHER)
ONCOLMMUNIN
ORIGENE TECHNOLOGIES
PERKINELMER
PROMEGA CORP.
ROCHE GROUP
STEMCELLS INC.
THERMO FISHER SCIENTIFIC
TTP LABTECH
VIVO BIOSCIENCES
VITRO BIOPHARMA

Chapter 10 Legal Aspects of Cell-based Assays

Intellectual Property Landscape for Cell-based Assays

  • Recent News, Alliances and Mergers
  • Summary and Outlook

Chapter 11 Appendix: Bibliography

List of Tables

Summary Table : Global Market for Cell-based Assays, by Segment, Through 2023
Table 1 : Estimated U.S. Medical and Health Research Expenditures and Percentage of Total Spending at Academic and Research Institutions
Table 2 : Uses of Cell-based Assays by Area
Table 3 : Types of Cell-based Assays
Table 4 : Apoptotic Markers
Table 5 : Proof of Concept for Cell-based Assays
Table 6 : Global Market for Cell-based Assays, Through 2023
Table 7 : Materials and Manufacturers of Hydrogels, by Type
Table 8 : Minimum Requirements for Organ-on-a-Chip Units, by Type
Table 9 : HCS Instrumentation Available in the Market, by Company
Table 10 : HCS Informatics Tools Available in the Market, by Application
Table 11 : Selected High-throughput Instruments Available in the Market
Table 12 : Biological Assay Systems for the Evaluation of Cytochrome P450 Enzyme Isoforms
Table 13 : Types of Hepatocyte Assay Systems
Table 14 : Types of ADME Assays
Table 15 : Common Types of Toxicity Assays
Table 16 : Traditional Methods of ADME/Tox Testing
Table 17 : Conventional In vitro ADME/Tox Screening Methods
Table 18 : Applications of Label-free Assays
Table 19 : Factors for Cell-based Assay Development
Table 20 : Approaches to Cell-based Systems for Drug Screening
Table 21 : List of Current Confocal HCS Platforms
Table 22 : Widefield HCS Platforms, by Type
Table 23 : List of Studies for Filing an Investigational New Drug Application
Table 24 : List of Studies for Clinical Filings
Table 25 : List of Existing Cell-based Assay Technologies
Table 26 : Biological Applications for High-Content Analysis
Table 27 : Global Market for Cell Biology Reagents and Tools, Through 2023
Table 28 : Global Market for High-throughput Screening, Through 2023
Table 29 : Key Companies for High-throughput Screening Technologies
Table 30 : Global Market for Drug Discovery Technologies, Through 2023
Table 31 : Key Companies for Drug Discovery Technologies
Table 32 : Global Market for Tools and Reagents Used in Life Sciences Research, Through 2023
Table 33 : Global Market for Cell Culture, Through 2023
Table 34 : Cell Culture Reagent Types
Table 35 : Global Market for Cell Culture Reagents, Through 2023
Table 36 : U.S. Market for Cell Culture, Through 2023
Table 37 : Global Market for 3D Cell Culture, Through 2023
Table 38 : 3D Cell Culture Technologies
Table 39 : Key Companies in Cell-based Assays
Table 40 : Cell-based Assay Market Segments
Table 41 : Global Market for Cell-based Assays, Through 2023
Table 42 : Limitations of Cell-based Assays
Table 43 : Global Market for Cell-based Assays Used in Basic Research, Through 2023
Table 44 : Areas Using In Vitro Toxicology Testing
Table 45 : Global Market for 3D Cell Culture, Through 2023
Table 46 : Global Market for Specialized Cell-based Assays Used in Drug Discovery, Through 2023
Table 47 : In Vitro Predictive Toxicology Assays
Table 48 : 3D Microtissue and Spheroid Models
Table 49 : Global Market for ADME Assays, Through 2023
Table 50 : List of Key Companies in ADME Assays
Table 51 : Major Companies in the High-Content Screening Market
Table 52 : Products Offered by Molecular Devices
Table 53 : High-content Screening System Platforms
Table 54 : Millipore Product Applications
Table 55 : Global Market for High-Content Screening Instruments, Through 2023
Table 56 : Key Flow Cytometry Companies
Table 57 : Assay Methods Used to Study GPCRs
Table 58 : GPCR Primary Screening Assays
Table 59 : Key GPCR Targeting Drugs
Table 60 : Key Companies with GPCR Products
Table 61 : Omeros' GPCRs and Their Indications
Table 62 : Thermo Fisher's Products
Table 63 : Thermo Fisher's Cell-based Technologies
Table 64 : Key Growth Drivers of the Cell-based Assay Market
Table 65 : Global Market for Cell-based Assays, by Region, Through 2023
Table 66 : North American Market for Cell-based Assays, Through 2023
Table 67 : U.S. Market for Cell-based Assays, Through 2023
Table 68 : European Market for Cell-based Assays, Through 2023
Table 69 : Chinese Market for Drug Discovery Outsourcing, Through 2023
Table 70 : Indian Market for Drug Discovery Products, Through 2023"

List of Figures

Summary Figure : Global Market for Cell-based Assays, by Segment, 2017-2023
Figure 1 : Projected Global Aging Population (60 Years and Above), 1990-2100
Figure 2 : Drug Discovery Process Steps
Figure 3 : Global Market for Cell-based Assays, 2017-2023
Figure 4 : Process Flow for Patient-derived Organoid Cell Assay
Figure 5 : Basic Architecture of Organ-on-a-Chip Systems
Figure 6 : Shares of Approved Drugs with Unique GPCRs, 2017
Figure 7 : Cell Viability and Kinase Assays Used to Measure Change in ATP Levels
Figure 8 : Shares of Common Diseases Registered for Mesenchymal Stromal Cell-based Therapy, 2016
Figure 9 : Global Market for Cell Biology Reagents and Tools, 2017-2023
Figure 10 : Global Market for Drug Discovery Technologies, 2017-2023
Figure 11 : Global Market for Tools and Reagents Used in Life Sciences Research, 2017-2023
Figure 12 : Global Market for Cell Culture, 2017-2023
Figure 13 : Global Market for Cell Culture Reagents, 2017-2023
Figure 14 : U.S. Market for Cell Culture, 2017-2023
Figure 15 : Global Market for 3D Cell Culture, 2017-2023
Figure 16 : Global Market for Cell-based Assays, 2017-2023
Figure 17 : Global Market for Cell-based Assays Used in Basic Research, 2017-2023
Figure 18 : Global Market for 3D Cell Culture, 2017-2023
Figure 19 : Global Market for Specialized Cell-based Assays Used in Drug Discovery, 2017-2023
Figure 20 : Phase Transition Success Rates and Likelihood of Approval from Phase I for all Diseases, all Modalities, 2005-2016
Figure 21 : Global Market for ADME Assays, 2017-2023
Figure 22 : Global Market for High-Content Screening Instruments, 2017-2023
Figure 23 : Global Market for Cell-based Assays, by Region, 2017-2023
Figure 24 : North American Market for Cell-based Assays, 2017-2023
Figure 25 : U.S. Market for Cell-based Assays, 2017-2023
Figure 26 : European Market for Cell-based Assays, 2017-2023
Figure 27 : Chinese Market for Drug Discovery Outsourcing, 2017-2023
Figure 28 : Indian Market for Drug Discovery Products, 2017-2023


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